Polyclonal integration of HTLV‐I proviral DNA in lymphocytes from HTLV‐I seropositive individuals: an intermediate state between the healthy carrier state and smouldering ATL
Polyclonal integration of HTLV‐I proviral DNA in lymphocytes from HTLV‐I seropositive individuals: an intermediate state between the healthy carrier state and smouldering ATL
复制标题
HTLV-I 血清阳性个体淋巴细胞中 HTLV-I 前病毒 DNA 的多克隆整合：健康携带者状态和阴燃 ATL 之间的中间状态
DOI：
--
复制
发表时间：
1988
影响因子：
6.5
通讯作者：
K. Takatsuki
中科院分区：
文献类型：
--
作者：
K. Yamaguchi;T. Kiyokawa;K. Nakada;L. S. Yul;N. Asou;T. Ishii;I. Sanada;M. Seiki;Mitsuaki Yoshida;E. Matutes;D. Catovsky;K. Takatsuki
我们研究了15名血清中有HTLV‐I抗体且外周血淋巴细胞中随机整合有HTLV ‐I前病毒DNA的个体（年龄14 - 74岁）。除1例患者外，所有这些患者均患有各种非特异性主诉，与成人T细胞白血病（ATL）不对应。所有受试者均出生于九州和冲绳，这两个地区是HTLV-I感染的流行区;其25%的家庭成员也为HTLV-I血清阳性。这些患者唯一的血液学异常是外周血中存在少量非典型淋巴细胞。CD 4/CD 8比值正常，但Tac阳性细胞比例略高于正常。
We have studied 15 individuals (aged 14‐74 years) with antibodies to HTLV‐I in their serum and random integration of HTLV‐I proviral DNA in their peripheral blood lymphocytes. All but one of these patients suffered from a variety of non‐specific complaints which did not correspond to those of adult T‐cell leukaemia (ATL). All of them were born in Kyushu and Okinawa which are endemic areas for HTLV‐I infection; 25% of their family members were also seropositive for HTLV‐I. The only haematological abnormality in these patients was the presence of few atypical lymphoid cells in the peripheral blood. The CD4/CD8 ratios were normal but the proportion of Tac positive cells was slightly higher than normal.
HTLV-II 的反式激活基因诱导 IL-2 受体和 IL-2 细胞基因表达。
DOI：
10.1126/science.3010456
发表时间：
1986
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Greene,WC;Leonard,WJ;Wano,Y;Svetlik,PB;Peffer,NJ;Sodroski,JG;Rosen,CA;Goh,WC;Haseltine,WA
通讯作者：
Haseltine,WA
DOI：
10.1073/pnas.79.24.7824
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
DALLAFAVERA, R;BREGNI, M;CROCE, CM
通讯作者：
CROCE, CM