Mapping the neuropsychological profile of temporal lobe epilepsy using cognitive network topology and graph theory.
Mapping the neuropsychological profile of temporal lobe epilepsy using cognitive network topology and graph theory.
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DOI：
10.1016/j.yebeh.2016.07.030
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Hermann BP
中科院分区：
文献类型：
--
作者：
Kellermann TS;Bonilha L;Eskandari R;Garcia-Ramos C;Lin JJ;Hermann BP
正常的认知功能是由多个神经心理域之间的和谐互动所定义的。癫痫对认知有破坏性影响，但与健康对照（HC）相比，不同的认知能力是如何相互作用的尚不清楚。本研究运用图论分析成人颞叶癫痫（TLE）与HC的认知网络共同体结构。对100例TLE患者和82例HC患者进行神经心理评估。对于每一组，构建一个邻接矩阵，表示在每个可能的测试组合中获得的原始分数之间的成对相关系数。对于每个认知网络，每个节点对应一个认知测试；每个环节对应测试之间的相关系数。对全局网络结构、群落结构和节点图论性质进行了定性评价。TLE患者的社区结构由更少、更大、更混合的模块组成，主要有三个模块，它们之间的关系密切：1)执行功能（EF）、言语和视觉记忆；2)速度和流畅性；3)速度、EF、感知、语言、智力和非语言记忆。相反，对照组在认知功能之间表现出相对的分裂，分离成更多、更小的模块，包括：1)言语记忆，2)语言、感知和智力，3)速度和流利，4)视觉记忆和EF。整体节点聚类系数和效率在TLE中有所提高。患有TLE的成年人在多个认知领域之间表现出不太清晰和结构不佳的隔离。这幅全景图表明，TLE中多个认知领域的相互依赖程度更高，可能表明克服功能障碍的代偿机制。
Normal cognitive function is defined by harmonious interaction among multiple neuropsychological domains. Epilepsy has a disruptive effect on cognition, but how diverse cognitive abilities differentially interact with one another compared to healthy controls (HC) is unclear. This study used graph theory to analyze the community structure of cognitive networks in adults with temporal lobe epilepsy (TLE) compared with HC. Neuropsychological assessment was performed in 100 patients with TLE and 82 HC. For each group, an adjacency matrix was constructed representing pair-wise correlation coefficients between raw scores obtained in each possible test-combination. For each cognitive network, each node corresponded to a cognitive test; each link corresponded to the correlation coefficient between tests. Global network structure, community structure and node-wise graph theory properties were qualitatively assessed. The community structure in patients with TLE was composed of fewer, larger, more mixed modules, characterizing three main modules representing close relationships between: 1) aspects of executive function (EF), verbal and visual memory, 2) speed and fluency, and 3) speed, EF, perception, language, intelligence, and nonverbal memory. Conversely, controls exhibited a relative division between cognitive functions, segregating into more numerous, smaller modules consisting of: 1) verbal memory, 2) language, perception and intelligence, 3) speed and fluency, and 4) visual memory and EF. Overall node-wise clustering coefficient and efficiency were increased in TLE. Adults with TLE demonstrate a less clear and poorly structured segregation between multiple cognitive domains. This panorama suggests a higher degree of interdependency across multiple cognitive domains in TLE, possibly indicating compensatory mechanisms to overcome functional impairments.
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影响因子：
5.7
作者：
Kellermann TS;Caspers S;Fox PT;Zilles K;Roski C;Laird AR;Turetsky BI;Eickhoff SB
通讯作者：
Eickhoff SB
DOI：
10.1097/00004583-200502000-00010
发表时间：
2005-02-01
影响因子：
13.3
作者：
Klingberg, T;Fernell, E;Westerberg, H
通讯作者：
Westerberg, H
影响因子：
5.6
作者：
Engel, Jerome, Jr.
通讯作者：
Engel, Jerome, Jr.
DOI：
10.1016/s0022-5371(73)80034-9
发表时间：
1973-01-01
期刊：
JOURNAL OF VERBAL LEARNING AND VERBAL BEHAVIOR
影响因子：
--
作者：
BUSCHKE, H
通讯作者：
BUSCHKE, H
影响因子：
4.8
作者：
Alessio, Andrea;Pereira, Fabricio R. S.;Cendes, Fernando
通讯作者：
Cendes, Fernando