Genetic basis of renal cellular dysfunction and the formation of kidney stones.
Genetic basis of renal cellular dysfunction and the formation of kidney stones.
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DOI：
10.1007/s00240-009-0201-9
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发表时间：
2009-08
影响因子：
--
通讯作者：
Canales, Benjamin K.
中科院分区：
文献类型：
--
作者：
Khan, Saeed R.;Canales, Benjamin K.
肾结石是肾脏内晶体形成和滞留的结果。晶体形成背后的驱动力是尿液相对于形成结石的盐类的过饱和度，这意味着当参与离子的浓度高于该盐类的热力学溶解度时，就会形成晶体。通过各种细胞的正常功能，包括那些排列在肾小管上的细胞，过饱和度水平被保持在较低的水平并得到控制。我们的假设是，晶体沉积，即在肾脏中的形成和滞留，是细胞功能受损的结果，细胞功能受损可能是内在的，也可能是由外部刺激和挑战引发的。细胞损伤或功能障碍通过影响钙、草酸和柠檬酸等参与离子的排泄来影响过饱和度，并导致高钙尿、高草酸尿或低柠檬酸尿。大分子结晶促进剂和抑制物的产生和排泄也依赖于肾上皮细胞的正常功能。不足或无效的结晶调节剂，如骨桥蛋白(OPN)、Tamm Horsfall蛋白(THP)、Bikunin(BK)等，很可能是由受损的细胞产生的。
Nephrolithiasis is a result of formation and retention of crystals within the kidneys. The driving force behind crystal formation is urinary supersaturation with respect to the stone forming salts, which means that crystals form when the concentrations of participating ions are higher than the thermodynamic solubility for that salt. Levels of supersaturation are kept low and under control by proper functioning of a variety of cells including those that line the renal tubules. It is our hypothesis that crystal deposition i.e. formation and retention in the kidneys, is a result of impaired cellular function, which may be intrinsic and inherent or triggered by external stimuli and challenges. Cellular impairment or dysfunction affects the supersaturation, by influencing the excretion of participating ions such as calcium, oxalate and citrate and causing hypercalciuria, hyperoxaluria or hypocitraturia. The production and excretion of macromolecular promoters and inhibitors of crystallization is also dependent upon proper functioning of the renal epithelial cells. Insufficient or ineffective crystallization modulators such as osteopontin (OPN), Tamm Horsfall protein (THP), bikunin (BK) etc are most likely produced by the impaired cells.
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影响因子：
--
作者：
Grases, F;Ramis, M;Costa-Bauzá, A
通讯作者：
Costa-Bauzá, A
影响因子：
19.6
作者：
Bushinsky, DA;Asplin, JR;Coe, FL
通讯作者：
Coe, FL
影响因子：
--
作者：
ATMANI, F;LACOUR, B;DAUDON, M
通讯作者：
DAUDON, M
影响因子：
4.5
作者：
Bernascone, Ilenia;Vavassori, Stefano;Rampoldi, Luca
通讯作者：
Rampoldi, Luca
DOI：
10.1111/j.1432-1033.1996.00984.x
发表时间：
1996-03-15
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Atmani, F;Mizon, J;Khan, SR
通讯作者：
Khan, SR