Persistent overweight or obesity, lung function, and asthma exacerbations in Puerto Rican youth.
Persistent overweight or obesity, lung function, and asthma exacerbations in Puerto Rican youth.
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DOI：
10.1016/j.anai.2022.01.004
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发表时间：
2022-04
期刊：
影响因子：
--
通讯作者：
Celedón JC
中科院分区：
文献类型：
--
作者：
Wong M;Han YY;Rosser F;Acosta-Pérez E;Canino G;Forno E;Celedón JC
持续超重或肥胖是否会影响年轻人的肺功能或哮喘发病率尚不清楚。检查从学龄期到青春期持续的超重或肥胖，以及波多黎各青年中肺功能和总IgE的变化，以及严重的哮喘恶化。对340名波多黎各青年的前瞻性研究在两次访问中进行了评估，第一次访问的年龄为6-14岁，第二次访问的年龄为9-20岁。在两次检查中，持续性超重或肥胖被定义为体重指数z-Score≥第85个百分位数。感兴趣的结果是在两次研究访问之间预测的肺功能指标和总IgE的百分比变化，以及访问前一年的严重哮喘恶化。多变量分析采用Logistic或线性回归。在多变量分析中，持续性超重或肥胖受试者的预计FEV1%(β=−5.07%，95%可信区间[CI]=−1.51%至−8.62%，P<；0.01)和预计FEV1/FVC的%(β=−2.85%，95%CI=−0.18%至−5.51%，P=0.04)均低于正常体重受试者(对照组)。与对照组相比，持续超重/肥胖者和在第二次访视时超重/肥胖者在第二次访视前一年发生≥-1重度哮喘的几率增加。持续超重/肥胖与预计FVC或总IgE的变化无显著关联。在一项对波多黎各青年的前瞻性研究中，持续超重或肥胖的受试者与正常体重的受试者相比，FEV1或FEV1/FVC的变化较小，严重哮喘加重的几率较高。
Whether persistent overweight or obesity impacts lung function or asthma morbidity in youth is unclear. To examine overweight or obesity that persists between school age and adolescence and change in lung function and total IgE, and severe asthma exacerbations in Puerto Rican youth. Prospective study of 340 Puerto Rican youth assessed at two visits, the first at ages 6–14 years and the second at ages 9–20 years. Persistent overweight or obesity was defined as a BMI z-score ≥85th percentile at both visits. Outcomes of interest were change in %predicted lung function measures and total IgE between study visits, and severe asthma exacerbations in the year prior to visit 2. Logistic or linear regression was used for the multivariable analysis. In a multivariable analysis, persistently overweight or obese subjects had changes in %predicted FEV1 (β= −5.07%, 95% confidence interval [CI]= −1.51% to −8.62%, P<0.01) and %predicted FEV1/FVC (β=−2.85%, 95% CI= −0.18% to −5.51%, P=0.04) that were lower than those observed in subjects with normal weight at both study visits (control subjects). Compared with control subjects, those who were persistently overweight/obese and those who became overweight/obese at visit 2 had increased odds of ≥1 severe asthma exacerbation in the year prior to visit 2. There was no significant association between persistent overweight/obesity and change in %predicted FVC or total IgE. In a prospective study of Puerto Rican youth, persistently overweight or obese subjects had lower changes in FEV1 or FEV1/FVC and higher odds of severe asthma exacerbations than subjects of normal weight.
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DOI：
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期刊：
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