Heart deformation analysis for automated quantification of cardiac function and regional myocardial motion patterns: A proof of concept study in patients with cardiomyopathy and healthy subjects.
Heart deformation analysis for automated quantification of cardiac function and regional myocardial motion patterns: A proof of concept study in patients with cardiomyopathy and healthy subjects.
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DOI：
10.1016/j.ejrad.2016.08.005
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发表时间：
2016-10
影响因子：
3.3
通讯作者：
Carr, James C.
中科院分区：
文献类型：
--
作者：
Lin, Kai;Collins, Jeremy D.;Chowdhary, Varun;Markl, Michael;Carr, James C.
目的：探讨HDA在基于心血管磁共振（CMR）的心肌病患者左室（LV）功能和局部心肌运动模式表征中的作用。经机构审查委员会（IRB）批准，采用HDA对45名受试者的标准电影图像进行回顾性分析，其中包括15名健康志愿者、15名肥厚型心肌病（HCM）患者和15名扩张型心肌病（DCM）患者。计算并比较各组左室射血分数（LVEF）、左室质量（LVM）和局部心肌运动指标（径向（Drr）、周向（Dcc）位移、径向（Vrr）和周向（Vcc）速度、径向（Err）、周向（Ecc）和剪切（Ess）应变以及径向（SRr）和周向（SRc）应变率）的变化。采用类内相关系数（ICC）和变异系数（CoV）对15名志愿者的hda心肌运动指数进行了研究间的可重复性检验。HDA鉴定出各组之间心功能和运动指标有显著差异。DCM患者LVEF（33.5±9.65%）、LVM（105.88±21.93g）、峰值Drr（0.29±0.11cm）、Vrr-sys（2.14±0.72cm/s）、Err（0.17±0.08）、Ecc（- 0.08±0.03）、SRr-sys（0.91±0.44s−1）、SRc-sys（- 0.64±0.27s−1）显著低于其他两组。HCM患者LVM升高（171.69±34.19），Vcc-dia峰值较其他受试者低（0.78±0.30 cm/s）。在健康志愿者中，所有hda衍生心肌指标的研究间可重复性良好（ICC = 0.664 ~ 0.942, CoV = 15.1% ~ 37.1%）。HDA是一种可重复的方法，可在心肌病背景下自动表征全局和局部左室功能，无需操作者的干预。
To test the performance of HDA in characterizing left ventricular (LV) function and regional myocardial motion patterns in the context of cardiomyopathy based on cine cardiovascular magnetic resonance (CMR). Following the approval of the institutional review board (IRB), standard cine images of 45 subjects, including 15 healthy volunteers, 15 patients with hypertrophic cardiomyopathy (HCM) and 15 patients with dilated cardiomyopathy (DCM) were retrospectively analyzed using HDA. The variations of LV ejection fraction (LVEF), LV mass (LVM), and regional myocardial motion indices, including radial (Drr), circumferential (Dcc) displacement, radial (Vrr) and circumferential (Vcc) velocity, radial (Err), circumferential (Ecc) and shear (Ess) strain and radial (SRr) and circumferential (SRc) strain rate, were calculated and compared among subject groups. Inter-study reproducibility of HDA-derived myocardial motion indices were tested on 15 volunteers by using intra-class correlation coefficient (ICC) and coefficient of variation (CoV). HDA identified significant differences in cardiac function and motion indices between subject groups. DCM patients had significantly lower LVEF (33.5 ± 9.65%), LVM (105.88 ± 21.93g), peak Drr (0.29 ± 0.11cm), Vrr-sys (2.14 ± 0.72cm/s), Err (0.17 ± 0.08), Ecc (−0.08 ± 0.03), SRr-sys (0.91 ± 0.44s−1) and SRc-sys (−0.64 ± 0.27s−1) compared to the other two groups. HCM patients demonstrated increased LVM (171.69 ± 34.19) and lower peak Vcc-dia (0.78 ± 0.30 cm/s) than other subjects. Good inter-study reproducibility was found for all HDA-derived myocardial indices in healthy volunteers (ICC = 0.664 - 0.942, CoV = 15.1% - 37.1%). Without the need for operator interaction, HDA is a reproducible method for the automated characterization of global and regional LV function in the context of cardiomyopathy.
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DOI：
10.1186/1532-429x-16-10
发表时间：
2014-01-22
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Wu L;Germans T;Güçlü A;Heymans MW;Allaart CP;van Rossum AC
通讯作者：
van Rossum AC
影响因子：
3
作者：
Sugimori, Hiroyuki;Oyama-Manabe, Noriko;Sakata, Motomichi
通讯作者：
Sakata, Motomichi
DOI：
10.1186/1532-429x-14-43
发表时间：
2012-06-21
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Morton G;Schuster A;Jogiya R;Kutty S;Beerbaum P;Nagel E
通讯作者：
Nagel E
影响因子：
24
作者：
Gersh, Bernard J.;Maron, Barry J.;Yancy, Clyde W.
通讯作者：
Yancy, Clyde W.
影响因子：
37.8
作者：
Maron, BJ;Towbin, JA;Young, JB
通讯作者：
Young, JB