Cortical feedback modulates distinct critical period development in mouse visual thalamus.
Cortical feedback modulates distinct critical period development in mouse visual thalamus.
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皮质反馈调节小鼠视觉丘脑的不同关键期发育
DOI：
10.1016/j.isci.2022.105752
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发表时间：
2023-01-20
期刊：
影响因子：
5.8
通讯作者：
Gu, Yu
中科院分区：
文献类型：
--
作者：
Li, Na;Liu, Qiong;Zhang, Yimu;Yang, Zhongyi;Shi, Xuefeng;Gu, Yu
在初级视皮层（V1），眼优势（OD）可塑性的关键期是一个明确的发展阶段，形成基于视觉经验的神经回路。最近的研究表明，小鼠外侧膝状体背侧核（dLGN）内存在V1样OD可塑性。目前尚不清楚确切的时间窗口是什么以及神经回路如何影响dLGN的OD可塑性。使用体内电生理学，我们定义了一个关键时期的OD可塑性dLGN从眼睛开放到青春期。在dLGN双眼神经元中也存在一个从对侧到等偏的OD形成的先天过程。瞬时V1灭活蝇蕈醇对OD偏差或可塑性没有影响。短期V1失活与N-甲基-D-天冬氨酸逆转形成相等的OD偏差，而长期V1失活保留dLGN发展到一个不成熟的阶段。在P24时，dLGN双眼神经元OD由对侧向等偏性转变。dLGN OD可塑性的经验依赖性关键期为P14-P30。短期V1失活逆转了dLGN OD偏性的形成。长期V1失活使dLGN发育维持在未成熟阶段。生物科学;发育神经科学;感觉神经科学
In primary visual cortex (V1), critical period for ocular dominance (OD) plasticity is a well-defined developmental stage to shape neuronal circuits based on visual experience. Recent studies showed that V1-like OD plasticity existed in mouse dorsal lateral geniculate nucleus (dLGN). It is still unclear what the exact time window is and how neural circuits contribute to OD plasticity in dLGN. Using in vivo electrophysiology, we defined a critical period for OD plasticity in dLGN from eye opening to puberty. There also existed an innate process of OD formation from contralateral to equal bias in dLGN binocular neurons. Instant V1 inactivation with muscimol had no effect on OD bias or plasticity. Short-term V1 inactivation with N-methyl-d-aspartate reversed the formation of equal OD bias, while long-term V1 inactivation retained dLGN development to an immature stage. The OD of dLGN binocular neurons transformed from contralateral to equal bias at P24 The experience-dependent critical period for OD plasticity was from P14 to P30 in dLGN Short-term V1 inactivation reversed the formation of OD bias in dLGN Long-term V1 inactivation retained the development of dLGN to an immature stage Biological sciences; Developmental neuroscience; Sensory neuroscience
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影响因子：
25
作者：
McCurry, Cortina L.;Shepherd, Jason D.;Tropea, Daniela;Wang, Kuan H.;Bear, Mark F.;Sur, Mriganka
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Sur, Mriganka
影响因子：
16.2
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Stryker MP
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3.9
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Hong, Y. Kate;Park, SuHong;Litvina, Elizabeth Y.;Morales, Jose;Sanes, Joshua R.;Chen, Chinfei
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