Diabetes and cancer: two diseases with obesity as a common risk factor.
Diabetes and cancer: two diseases with obesity as a common risk factor.
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DOI：
10.1111/dom.12124
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发表时间：
2014-02
期刊：
影响因子：
--
通讯作者：
Selagamsetty R
中科院分区：
文献类型：
--
作者：
Garg SK;Maurer H;Reed K;Selagamsetty R
越来越多的证据支持糖尿病（主要是2型糖尿病），肥胖和癌症之间的联系。对流行病学数据的多项荟萃分析显示，糖尿病患者患多种不同类型癌症的风险增加，沿着癌症死亡风险增加。已经假设了这种关系的几种病理生理学机制，包括胰岛素抵抗和高胰岛素血症、增强的炎症过程、性激素产生失调和高胰岛素血症。除了这些潜在的机制，一些常见的风险因素，包括肥胖，可能是糖尿病和癌症之间的关联背后。事实上，肥胖与癌症和糖尿病的风险增加有关。腹部肥胖已被证明在创造全身促炎环境中发挥作用，这可能导致糖尿病和癌症的发展。在这里，我们研究了糖尿病，肥胖和癌症之间的关系，并调查了糖尿病患者癌症风险增加的潜在原因。目前的治疗建议，以减少整体疾病负担也进行了探讨，并考虑未来研究的可能领域。
There is a growing body of evidence to support a connection between diabetes (predominantly type 2), obesity and cancer. Multiple meta-analyses of epidemiological data show that people with diabetes are at increased risk of developing many different types of cancers, along with an increased risk of cancer mortality. Several pathophysiological mechanisms for this relationship have been postulated, including insulin resistance and hyperinsulinaemia, enhanced inflammatory processes, dysregulation of sex hormone production and hyperglycaemia. In addition to these potential mechanisms, a number of common risk factors, including obesity, may be behind the association between diabetes and cancer. Indeed, obesity is associated with an increased risk of cancer and diabetes. Abdominal adiposity has been shown to play a role in creating a systemic pro-inflammatory environment, which could result in the development of both diabetes and cancer. Here, we examine the relationship between diabetes, obesity and cancer, and investigate the potential underlying causes of increased cancer risk in individuals with diabetes. Current treatment recommendations for reducing the overall disease burden are also explored and possible areas for future research are considered.
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