Measurement of Liver Stiffness Using Shear Wave Elastography in a Rat Model: Factors Impacting Stiffness Measurement with Multiple- and Single-Tracking-Location Techniques.
Measurement of Liver Stiffness Using Shear Wave Elastography in a Rat Model: Factors Impacting Stiffness Measurement with Multiple- and Single-Tracking-Location Techniques.
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DOI：
10.1016/j.ultrasmedbio.2017.07.004
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发表时间：
2017-11
影响因子：
2.9
通讯作者：
McAleavey SA
中科院分区：
文献类型：
--
作者：
Langdon JH;Elegbe E;Gonzalez RS;Osapoetra L;Ford T;McAleavey SA
弹性成像监测纤维化进展的临床应用受到与早期纤维化相关的肝脏硬度的细微变化的挑战，以及弹性成像提供的硬度估计的相对较大的差异。单跟踪位置剪切波弹性成像(STL-SWEI)是一种超声弹性成像技术，先前已被证明与多跟踪位置(MTL)SWEI相比可提供更高的估计精度。由于精密度的提高，与MTL-Swei相比，STL-Swei将提供更好的区分肝纤维化分期的能力，这是合理的。然而，这一预期此前并未受到严厉挑战。在这项工作中，STL-Swei和MTL-Swei在建立大鼠肝纤维化模型中的表现进行了表征，并探讨了STL-Swei在肝纤维化分期中的优势。本研究的目的是确定在肝纤维化的定性中使用STL-Swei而不是MTL-Swei有什么优势。因此，探讨了STL-Swei在体外、死后测量中区分不同METAVIR纤维化评分的肝脏的能力。此外，我们还考察了流体与固体边界条件在Swei实验中的常见混杂因素的影响。用四氯化碳治疗SpragueDawley大鼠数周，造成不同严重程度的肝病。在体外进行STL和MTL硬度测量，并与来自组织学分析和治疗持续时间的METAVIR评分进行比较。观察到肝脏僵硬与肝脏毒素四氯化碳治疗数周的相关性很强。直接比较STL-和MTL-Swei测量结果显示，根据Swei图像平均值区分纤维化分期的能力没有显著差异。然而，在小波束间隔情况下，与MTL-Swei相比，在STL-Swei成像的情况下，图像四分位数范围得到了极大的改善。
The clinical use of elastography for monitoring fibrosis progression is challenged by the subtle changes in liver stiffness associated with early stage fibrosis, and the comparatively large variance of stiffness estimates provided by elastography. Single Tracking Location Shear Wave Elasticity Imaging (STL-SWEI) is an ultrasound elastography technique that was previously demonstrated to provide improved estimate precision compared to Multiple Tracking Location (MTL) SWEI. As a result of improved precision, it is reasonable to expect that STL-SWEI would provide improved ability to differentiate liver fibrosis stage compared to MTL-SWEI. However, this expectation has not been previously challenged rigorously. In this work, the performance of STL- and MTL-SWEI in the setting of a rat model of liver fibrosis is characterized and the advantages of STL-SWEI in staging fibrosis are explored. The purpose of this study is to determine what advantages, if any, arise from utilizing STL-SWEI instead of MTL-SWEI in the characterization of fibrotic liver. Thus, the ability of STL-SWEI to differentiate livers at various METAVIR fibrosis scores, for ex vivo, post-mortem measurements, is explored. In addition, we examine the effect of the common confounding factor of fluid versus solid boundary conditions in SWEI experiments. Sprague-Dawley rats are treated with carbon tetrachloride over several weeks to produce liver disease of varying severity. STL and MTL stiffness measurements were performed ex vivo and compared to the METAVIR score from histological analysis and the duration of treatment. A strong association was observed between liver stiffness and weeks of treatment with the liver toxin carbon tetrachloride. Direct comparison of STL- and MTL-SWEI measurements show no significant difference in ability to differentiate fibrosis stages based on SWEI image mean values. However, image interquartile range is greatly improved in the case of STL-SWEI imaging compared to MTL-SWEI at small beam spacings.
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