CD24 expression as a marker for predicting clinical outcome in human gliomas.
CD24 expression as a marker for predicting clinical outcome in human gliomas.
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DOI：
10.1155/2012/517172
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发表时间：
2012
影响因子：
--
通讯作者：
Zhao Z
中科院分区：
文献类型：
--
作者：
Deng J;Gao G;Wang L;Wang T;Yu J;Zhao Z
CD24 在体外和体内的神经胶质瘤细胞中过度表达。然而，其表达与神经胶质瘤临床病理参数的相关性及其在该肿瘤中的预后意义仍然很大程度上未知。为了解决这个问题，收集了 151 份神经胶质瘤标本和 10 份非肿瘤性脑组织。进行实时定量PCR、免疫化学测定和Western blot分析来研究CD24的表达。根据结果，CD24 在神经胶质瘤中过度表达。其在高级别（P < 0.001）和低KPS（P < 0.001）胶质瘤组织中的表达水平分别显着高于低级别和高KPS的胶质瘤组织。 Cox多因素分析显示CD24（P = 0.02）是人胶质瘤的独立预后因素。我们的数据首次提供了令人信服的证据，表明 CD24 在基因和蛋白质水平上的过度表达与神经胶质瘤患者的晚期临床病理参数和不良预后相关。
CD24 is overexpressed in glioma cells in vitro and in vivo. However, the correlation of its expression with clinicopathological parameters of gliomas and its prognostic significance in this tumor remain largely unknown. To address this problem, 151 glioma specimens and 10 nonneoplastic brain tissues were collected. Quantitative real-time PCR, immunochemistry assay, and Western blot analysis were carried out to investigate the expression of CD24. As per the results, CD24 was overexpressed in gliomas. Its expression levels in glioma tissues with higher grade (P < 0.001) and lower KPS (P < 0.001) were significantly higher than those with lower grade and higher KPS, respectively. Cox multifactor analysis showed that CD24 (P = 0.02) was an independent prognosis factor for human glioma. Our data provides convincing evidence for the first time that the overexpression of CD24 at gene and protein levels is correlated with advanced clinicopathological parameters and poor prognosis in patients with glioma.
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影响因子：
8.8
作者：
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影响因子：
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3.7
作者：
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DOI：
10.1097/00005072-199908000-00002
发表时间：
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影响因子：
3.2
作者：
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通讯作者：
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