Elevated Polyamines in Saliva of Pancreatic Cancer.
Elevated Polyamines in Saliva of Pancreatic Cancer.
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DOI：
10.3390/cancers10020043
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发表时间：
2018-02-05
期刊：
影响因子：
5.2
通讯作者：
Sunamura M
中科院分区：
文献类型：
--
作者：
Asai Y;Itoi T;Sugimoto M;Sofuni A;Tsuchiya T;Tanaka R;Tonozuka R;Honjo M;Mukai S;Fujita M;Yamamoto K;Matsunami Y;Kurosawa T;Nagakawa Y;Kaneko M;Ota S;Kawachi S;Shimazu M;Soga T;Tomita M;Sunamura M
由于缺乏准确的检测试验，在可切除阶段检测胰腺癌（PC）仍然很困难。在低或非侵入性生物流体中开发准确的生物标志物对于频繁进行测试至关重要，这将有助于增加早期PC检测的机会。多胺已被报道为各种癌症的尿液和唾液样本中可能的生物标志物。在这里，我们使用毛细管电泳-质谱法分析了唾液代谢物，包括多胺。从PC患者（n = 39）、慢性胰腺炎患者（CP，n = 14）和对照组（C，n = 26）中采集唾液样本。多胺，如精胺，N1-乙酰亚精胺，N1-乙酰精胺，表现出显着的差异与PC和C患者之间，和四个代谢产物的组合，包括N1-乙酰亚精胺显示出较高的准确性区分PC从其他两组。这些数据显示了唾液作为PC筛查测试来源的潜力。
Detection of pancreatic cancer (PC) at a resectable stage is still difficult because of the lack of accurate detection tests. The development of accurate biomarkers in low or non-invasive biofluids is essential to enable frequent tests, which would help increase the opportunity of PC detection in early stages. Polyamines have been reported as possible biomarkers in urine and saliva samples in various cancers. Here, we analyzed salivary metabolites, including polyamines, using capillary electrophoresis-mass spectrometry. Salivary samples were collected from patients with PC (n = 39), those with chronic pancreatitis (CP, n = 14), and controls (C, n = 26). Polyamines, such as spermine, N1-acetylspermidine, and N1-acetylspermine, showed a significant difference between patients with PC and those with C, and the combination of four metabolites including N1-acetylspermidine showed high accuracy in discriminating PC from the other two groups. These data show the potential of saliva as a source for tests screening for PC.
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影响因子：
--
作者：
Mehta KY;Wu HJ;Menon SS;Fallah Y;Zhong X;Rizk N;Unger K;Mapstone M;Fiandaca MS;Federoff HJ;Cheema AK
通讯作者：
Cheema AK
影响因子：
3.7
作者：
Okuma N;Saita M;Hoshi N;Soga T;Tomita M;Sugimoto M;Kimoto K
通讯作者：
Kimoto K
DOI：
10.1016/s0006-291x(88)80042-1
发表时间：
1988-11-30
影响因子：
3.1
作者：
CHANG, BK;LIBBY, PR;PORTER, CW
通讯作者：
PORTER, CW
影响因子：
5.6
作者：
Itoi T;Sugimoto M;Umeda J;Sofuni A;Tsuchiya T;Tsuji S;Tanaka R;Tonozuka R;Honjo M;Moriyasu F;Kasuya K;Nagakawa Y;Abe Y;Takano K;Kawachi S;Shimazu M;Soga T;Tomita M;Sunamura M
通讯作者：
Sunamura M
影响因子：
4
作者：
Sugimoto M;Kawakami M;Robert M;Soga T;Tomita M
通讯作者：
Tomita M