One-year follow-up of chest CT findings in patients after SARS-CoV-2 infection.
One-year follow-up of chest CT findings in patients after SARS-CoV-2 infection.
复制标题
DOI：
10.1186/s12916-021-02056-8
复制
发表时间：
2021-08-09
期刊：
影响因子：
9.3
通讯作者：
Xu K
中科院分区：
文献类型：
--
作者：
Chen Y;Ding C;Yu L;Guo W;Feng X;Yu L;Su J;Xu T;Ren C;Shi D;Wu W;Yi P;Liu J;Tao J;Lang G;Li Y;Xu M;Sheng J;Li L;Xu K
对于新冠肺炎的1年成果，人们知之甚少。本研究的目的是追踪和评估新冠肺炎患者出院后连续CT扫描的肺部异常。对浙江大学医学院附属第一医院收治的新冠肺炎患者进行前瞻性队列研究，分别于入院时、出院后2 周、1 月、3 月、6 月、1 年进行胸部CT检查。并对1 时残留CT阴影的危险因素及残留CT异常对肺功能的影响进行评估。在这项研究中，共有41名患者接受了跟踪调查。连续CT评分证实出院后逐渐恢复。约47%的患者在出院后1年时肺部CT表现为残留像差，CT评分中位数为0(四分位数范围0~2)，以磨玻璃样阴影(GGO)为主。有残留放射学异常的患者年龄较大(p=0.004.0 1)，现有吸烟者的发生率较高(p=0.0 4)，高血压患者的发生率较高(p=0.0 5)，血氧饱和度较低(p=0.004)，急性期继发细菌感染的发生率较高(p=0.0 2)。多因素Logistic回归分析显示，年龄是残留放射学异常的危险因素(OR 1.08，95%CI 1.01-1.15，p=0.02)。残存CT异常者肺功能指标总肺活量(p=0.008)和残气量(p<；0.001)降低，且与CT评分呈负相关。在出院后1年的随访中，新冠肺炎幸存者的胸部CT表现持续改善。然而，仍然可以观察到残留的病变，并与肺体积参数相关。发生残留CT阴影的风险随着年龄的增长而增加。网上版载有补充材料，可在10.1186/s12916-021-02056-8查阅。
Knowledge about the 1-year outcome of COVID-19 is limited. The aim of this study was to follow-up and evaluate lung abnormalities on serial computed tomography (CT) scans in patients with COVID-19 after hospital discharge. A prospective cohort study of patients with COVID-19 from the First Affiliated Hospital, Zhejiang University School of Medicine was conducted, with assessments of chest CT during hospitalization and at 2 weeks, 1 month, 3 months, 6 months, and 1 year after hospital discharge. Risk factors of residual CT opacities and the influence of residual CT abnormalities on pulmonary functions at 1 year were also evaluated. A total of 41 patients were followed in this study. Gradual recovery after hospital discharge was confirmed by the serial CT scores. Around 47% of the patients showed residual aberration on pulmonary CT with a median CT score of 0 (interquartile range (IQR) of 0–2) at 1 year after discharge, with ground-glass opacity (GGO) with reticular pattern as the major radiologic pattern. Patients with residual radiological abnormalities were older (p = 0.01), with higher rate in current smokers (p = 0.04), higher rate in hypertensives (p = 0.05), lower SaO2 (p = 0.004), and higher prevalence of secondary bacterial infections during acute phase (p = 0.02). Multiple logistic regression analyses indicated that age was a risk factor associated with residual radiological abnormalities (OR 1.08, 95% CI 1.01–1.15, p = 0.02). Pulmonary functions of total lung capacity (p = 0.008) and residual volume (p < 0.001) were reduced in patients with residual CT abnormalities and were negatively correlated with CT scores. During 1-year follow-up after discharge, COVID-19 survivors showed continuous improvement on chest CT. However, residual lesions could still be observed and correlated with lung volume parameters. The risk of developing residual CT opacities increases with age. The online version contains supplementary material available at 10.1186/s12916-021-02056-8.
登录
查看更多内容
影响因子：
10
作者：
Hui, DS;Joynt, GM;Sung, JJY
通讯作者：
Sung, JJY
影响因子：
5.8
作者：
Xie L;Liu Y;Fan B;Xiao Y;Tian Q;Chen L;Zhao H;Chen W
通讯作者：
Chen W
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
DOI：
10.4103/ijri.ijri_469_16
发表时间：
2017-07
期刊：
The Indian journal of radiology & imaging
影响因子：
--
作者：
Das KM;Lee EY;Singh R;Enani MA;Al Dossari K;Van Gorkom K;Larsson SG;Langer RD
通讯作者：
Langer RD
严重急性呼吸综合症对幸存者队列中肺功能，运动能力和生活质量的1年影响。
影响因子：
9.6
作者：
Hui DS;Wong KT;Ko FW;Tam LS;Chan DP;Woo J;Sung JJ
通讯作者：
Sung JJ