The 1-year impact of severe acute respiratory syndrome on pulmonary function, exercise capacity, and quality of life in a cohort of survivors.
The 1-year impact of severe acute respiratory syndrome on pulmonary function, exercise capacity, and quality of life in a cohort of survivors.
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严重急性呼吸综合症对幸存者队列中肺功能，运动能力和生活质量的1年影响。
DOI：
10.1378/chest.128.4.2247
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发表时间：
2005-10
期刊：
影响因子：
9.6
通讯作者：
Sung JJ
中科院分区：
文献类型：
--
作者：
Hui DS;Wong KT;Ko FW;Tam LS;Chan DP;Woo J;Sung JJ
检测严重急性呼吸综合征（SARS）幸存者的肺功能、运动能力和健康相关生活质量（HRQoL）。我们评估了在香港威尔斯亲王医院确诊SARS的幸存者，在症状发作后3个月、6个月和12个月。我们的评估包括：肺容量（肺总容量[TLC]、肺活量、残气量、功能残气量）、肺量测定（FVC、FEV 1）、肺一氧化碳弥散量（Dlco）、吸气和呼气呼吸肌强度、6分钟步行距离（6 MWD）、胸片（CXRs）和HRQoL（通过医学结局研究36项简表一般健康调查问卷）。97例患者完成了系列评估。有39例男性和58例女性患者，63例患者（70%）为医护人员（平均年龄，36.9岁[SD，9.5岁];体重指数，23.7 kg/m2 [SD，4.0 kg/m2]）。1年时，27例患者（27.8%）有异常CXR结果。4例患者（4.1%）、5例患者（5.2%）和23例患者（23.7%）的FVC、TLC和Dlco值分别<预测值的80%。12个月时的6 MWD为511.0 m（SD，89.8 m），高于3个月时（平均差异，47.0 m; 95%置信区间[CI]，31.8至62.1 m; p < 0.01），但与6个月时无差异（平均差异，9.7 m; 95% CI，− 4.4至23.8 m; p = 0.18）。6分钟步行距离低于同年龄组的正常对照组，12个月时HRQoL受损。需要入住ICU的患者（n = 31）与不需要入住ICU的患者相比，CXR评分较高（1.6 [SD，3.1] vs 0.4 [SD，1.1]; p = 0.04），预测FVC、TLC和Dlco百分比较低，但6 MWD和健康状况无差异。发病1年后，23.7%的幸存者的Dlco明显受损。SARS幸存者的运动能力和健康状况明显低于正常人群。
To examine pulmonary function, exercise capacity, and health-related quality of life (HRQoL) among severe acute respiratory syndrome (SARS) survivors. We evaluated survivors with confirmed SARS at the Prince of Wales Hospital, Hong Kong, at 3, 6, and 12 months after symptom onset. Our assessment included: lung volume (total lung capacity [TLC], vital capacity, residual volume, functional residual capacity), spirometry (FVC, FEV1), diffusing capacity of the lung for carbon monoxide (Dlco), inspiratory and expiratory respiratory muscle strength, 6-min walk distance (6MWD), chest radiographs (CXRs), and HRQoL by Medical Outcomes Study 36-Item Short-Form General Health Survey questionnaire. Ninety-seven patients completed the serial assessments. There were 39 male and 58 female patients, and 63 patients (70%) were health-care workers (mean age, 36.9 years [SD, 9.5 years]; body mass index, 23.7 kg/m2 [SD, 4.0 kg/m2]). At 1 year, 27 patients (27.8%) had abnormal CXR findings. Four patients (4.1%), 5 patients (5.2%), and 23 patients (23.7%) had FVC, TLC, and Dlco values < 80% of predicted values, respectively. The 6MWD at 12 months was 511.0 m (SD, 89.8 m), which was higher than at 3 months (mean difference, 47.0 m; 95% confidence interval [CI], 31.8 to 62.1 m; p < 0.01) but not different from 6 months (mean difference, 9.7 m; 95% CI, − 4.4 to 23.8 m; p = 0.18). The 6MWD was lower than that for normal control subjects of the same age groups, and there was impairment of HRQoL at 12 months. Patients who required ICU admission (n = 31) showed higher CXR scores (1.6 [SD, 3.1]; vs 0.4 [SD, 1.1]; p = 0.04) and lower percentage of predicted FVC, TLC, and Dlco than those who did not, but there were no differences in 6MWD and health status. Significant impairment in Dlco was noted in 23.7% of survivors 1 year after illness onset. Exercise capacity and health status of SARS survivors were remarkably lower than those of a normal population.
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影响因子：
10
作者：
Hui, DS;Joynt, GM;Sung, JJY
通讯作者：
Sung, JJY
影响因子：
3.3
作者：
Franks TJ;Chong PY;Chui P;Galvin JR;Lourens RM;Reid AH;Selbs E;McEvoy CP;Hayden CD;Fukuoka J;Taubenberger JK;Travis WD
通讯作者：
Travis WD
严重的急性呼吸综合症对身体状况和生活质量的影响。
影响因子：
4.3
作者：
Lau HM;Lee EW;Wong CN;Ng GY;Jones AY;Hui DS
通讯作者：
Hui DS
DOI：
10.1016/s0140-6736(04)16255-7
发表时间：
2004-05-22
期刊：
Lancet (London, England)
影响因子：
--
作者：
Cheng PK;Wong DA;Tong LK;Ip SM;Lo AC;Lau CS;Yeung EY;Lim WW
通讯作者：
Lim WW
影响因子：
10
作者：
Chan, JWM;Ng, CK;Li, PCK
通讯作者：
Li, PCK