The functional organisation of glia in the adult brain of Drosophila and other insects.
The functional organisation of glia in the adult brain of Drosophila and other insects.
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DOI：
10.1016/j.pneurobio.2010.01.001
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发表时间：
2010-04
影响因子：
6.7
通讯作者：
Meinertzhagen, Ian A.
中科院分区：
文献类型：
--
作者：
Edwards, Tara N.;Meinertzhagen, Ian A.
关键词：
这篇综述对成年果蝇和其他模式昆虫的神经胶质细胞进行了注释和分类，并描述了果蝇视叶中这些神经胶质细胞的发育起源。成人神经胶质细胞的功能根据其亚型和在大脑中的位置而有所不同。注释神经胶质细胞的任务基本上只针对果蝇叶片的神经胶质细胞完成，其中包括： 两种类型的表面神经胶质细胞 - 假盒状神经胶质细胞和有孔神经胶质细胞；两种类型的皮质神经胶质细胞——远端卫星神经胶质细胞和近端卫星神经胶质细胞；以及两种类型的神经胶质细胞——上皮神经胶质细胞和边缘神经胶质细胞。我们主张放弃术语“视网膜下神经胶质细胞”，该术语用于指代假盒状神经胶质细胞和有孔神经胶质细胞。其他神经丛含有类似的神经胶质亚型，但除了触角叶之外，这些还没有被详细描述。表面神经胶质细胞形成血脑屏障，调节物质进出神经系统的流动，无论是对于整个大脑，特别是视神经桩。皮质神经胶质细胞提供第二层屏障，包裹轴突束并将神经元细胞体与邻近的大脑区域及其下面的神经桩隔离。神经丛神经胶质细胞可以在成人中产生，并且鞘神经胶质细胞的亚型负责在华勒变性期间清除细胞碎片。神经丛鞘和星形胶质细胞样神经胶质细胞都可能参与清除细胞外空间的神经递质，从而改变突触处的组胺、谷氨酸和可能的多巴胺水平，最终影响行为。
This review annotates and categorises the glia of adult Drosophila and other model insects and describes the developmental origins of these in the Drosophila optic lobe. The functions of glia in the adult vary depending upon their sub-type and location in the brain. The task of annotating glia is essentially complete only for the glia of the fly's lamina, which comprise: two types of surface glia - the pseudocartridge and fenestrated glia; two types of cortex glia - the distal and proximal satellite glia; and two types of neuropile glia - the epithelial and marginal glia. We advocate that the term subretinal glia, as used to refer to both pseudocartridge and fenestrated glia, be abandoned. Other neuropiles contain similar glial subtypes, but other than the antennal lobes these have not been described in detail. Surface glia form the blood brain barrier, regulating the flow of substances into and out of the nervous system, both for the brain as a whole and the optic neuropiles in particular. Cortex glia provide a second level of barrier, wrapping axon fascicles and isolating neuronal cell bodies both from neighbouring brain regions and from their underlying neuropiles. Neuropile glia can be generated in the adult and a subtype, ensheathing glia, are responsible for cleaning up cellular debris during Wallerian degeneration. Both the neuropile ensheathing and astrocyte-like glia may be involved in clearing neurotransmitters from the extracellular space, thus modifying the levels of histamine, glutamate and possibly dopamine at the synapse to ultimately affect behaviour.
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DOI：
10.1196/annals.1417.006
发表时间：
2008-01-01
期刊：
MOLECULAR AND BIOPHYSICAL MECHANISMS OF AROUSAL, ALERTNESS, AND ATTENTION
影响因子：
--
作者：
Boothroyd, Catharine E.;Young, Michael W.
通讯作者：
Young, Michael W.
影响因子：
2.9
作者：
BRAZITIKOS, PD;TSACOPOULOS, M
通讯作者：
TSACOPOULOS, M
影响因子：
11.8
作者：
Behr, M;Riedel, D;Schuh, R
通讯作者：
Schuh, R
影响因子：
64.5
作者：
Bainton, RJ;Tsai, LTY;Heberlein, U
通讯作者：
Heberlein, U
影响因子：
2.5
作者：
Borycz, JA;Borycz, J;Meinertzhagen, IA
通讯作者：
Meinertzhagen, IA