Using well-defined Ag nanocubes as substrates to quantify the spatial resolution and penetration depth of surface-enhanced Raman scattering imaging.
Using well-defined Ag nanocubes as substrates to quantify the spatial resolution and penetration depth of surface-enhanced Raman scattering imaging.
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DOI：
10.1088/0957-4484/25/1/014007
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发表时间：
2014-01-10
期刊：
影响因子：
3.5
通讯作者：
Xia Y
中科院分区：
文献类型：
--
作者：
Moran CH;Rycenga M;Xia X;Cobley CM;Xia Y
表面增强拉曼散射(SERS)的多路复用能力和高灵敏度使这一新的成像手段在快速诊断方面特别有吸引力。以100 nm银纳米立方体为衬底，首次定量评价了表面增强拉曼散射成像的一些基本参数，如模糊、空间分辨率和穿透深度。我们的结果表明，SERS是一种高分辨率的成像技术，其模糊值为0.5微米，低于许多传统的方式，如乳房X光检查。测量的空间分辨率为1.1µm，表明通过调整成像步长到相同的长度尺度或不超过2µm，可以有效地采集SERS图像。SERS成像的主要缺点是其穿透深度受组织的散射和吸收的限制。我们证明，多个纳米粒子聚集导致的信号增强可以帮助克服这一潜在的体内成像障碍。
The multiplexing capability and high sensitivity of surface-enhanced Raman scattering (SERS) make this new imaging modality particularly attractive for rapid diagnosis. With 100-nm Ag nanocubes serving as the substrate, this work quantitatively evaluated, for the first time, some of the fundamental parameters of SERS imaging such as blur, spatial resolution, and penetration depth. Our results imply that SERS is a high-resolution imaging technique with a blur value of 0.5 µm that was lower than many traditional modalities such as mammography. The spatial resolution was measured to be 1.1 µm, suggesting that SERS images could be collected effectively by adjusting the imaging step size to the same length scale, or no more than 2 µm. The major drawback of SERS imaging is its penetration depth, which is limited by the scattering and absorption of tissues. We demonstrated that enhancement of signal caused by aggregation of multiple nanoparticles could help overcome this potential road-block to in vivo imaging.
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影响因子：
15
作者：
Xia, Xiaohu;Zeng, Jie;Oetjen, L. Kyle;Li, Qingge;Xia, Younan
通讯作者：
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影响因子：
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作者：
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影响因子：
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通讯作者：
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DOI：
10.1073/pnas.0813327106
发表时间：
2009-08-11
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
9.9
作者：
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通讯作者：
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