The Epidemiology of Peripheral Arterial Disease: Importance of Identifying the Population at Risk
The Epidemiology of Peripheral Arterial Disease: Importance of Identifying the Population at Risk
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外周动脉疾病的流行病学：识别高危人群的重要性
DOI：
10.1177/1358863x9700200310
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发表时间：
1997
影响因子：
3.5
通讯作者：
A. Fronek
中科院分区：
文献类型：
--
作者：
M. Criqui;J. Denenberg;R. Langer;A. Fronek
弗雷明汉研究和其他人口研究的数据表明，间歇性跛行 (IC) 在中年后期急剧增加，并且男性略高于女性。人群中的无创检测表明，外周动脉疾病 (PAD) 的真实患病率至少比根据报告的 IC 患病率预期高出五倍。外周动脉疾病与吸烟、糖尿病或糖耐量受损的相关性最强。 PAD 的其他危险因素包括高血压；高密度脂蛋白胆固醇水平低；以及高水平的甘油三酯、载脂蛋白 B、脂蛋白 (a)、同型半胱氨酸、纤维蛋白原和血液粘度。患有外周动脉疾病的人比没有外周动脉疾病的人更容易患冠心病和脑血管疾病。由于 PAD 患者发生非致命性和致命性心血管疾病 (CVD) 事件的风险很高，因此有 PAD 证据的个体应仔细检查整个心血管系统，并积极改变 CVD 危险因素。
Data from the Framingham Study and other population studies indicate that intermittent claudication (IC) sharply increases in late middle age and is somewhat higher among men than women. Noninvasive testing in populations indicates that the true prevalence of peripheral arterial disease (PAD) is at least five times higher than would be expected based on the reported prevalence of IC. Peripheral arterial disease correlates most strongly with cigarette smoking and either diabetes or impaired glucose tolerance. Other risk factors for PAD include hypertension; low levels of high-density lipoprotein cholesterol; and high levels of triglycerides, apolipoprotein B, lipoprotein(a), homocysteine, fibrinogen and blood viscosity. Individuals with PAD are more likely to have coronary heart disease and cerebrovascular disease than those without PAD. Because of the high risk of both nonfatal and fatal cardiovascular disease (CVD) events in PAD patients, individuals with evidence of PAD should undergo both a careful examination of the entire cardiovascular system and aggressive modification of CVD risk factors.
DOI：
10.1001/jama.1988.03410130125037
发表时间：
1988-10
期刊：
JAMA
影响因子：
--
作者：
M. Austin;J. Breslow;C. Hennekens;Julie E. Buring;W. Willett;R. Krauss
通讯作者：
M. Austin;J. Breslow;C. Hennekens;Julie E. Buring;W. Willett;R. Krauss
影响因子：
37.8
作者：
MALINOW, MR;KANG, SS;UPSON, B
通讯作者：
UPSON, B
影响因子：
37.8
作者：
HIATT, WR;HOAG, S;HAMMAN, RF
通讯作者：
HAMMAN, RF