3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer.
3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer.
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DOI：
10.1002/mrm.22233
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发表时间：
2010-02
影响因子：
3.3
通讯作者：
Vigneron, Daniel B.
中科院分区：
文献类型：
--
作者：
Hu, Simon;Lustig, Michael;Balakrishnan, Asha;Larson, Peder E. Z.;Bok, Robert;Kurhanewicz, John;Nelson, Sarah J.;Goga, Andrei;Pauly, John M.;Vigneron, Daniel B.
关键词：
通过利用动态核极化的超极化技术，在液态下核自旋的高极化使得能够以高信噪比直接监测体内13 C代谢物。由于超极化信号的T1衰减导致的采集时间限制需要加速成像方法，例如压缩感知，以获得最佳速度和空间覆盖。在本文中，一个新的回波平面13 C三维磁共振光谱成像（MRSI）压缩感知序列的设计和测试。该序列提供高达7.53倍的加速，重建伪影最少。该设计的关键是在回扫读出期间采用x和y梯度点以伪随机地欠采样kf-kx-ky空间。在仿真和体模实验中验证了该设计，其中测试了欠采样的限制和噪声对压缩感知非线性重构的影响。最后，这种新的脉冲序列在体内应用于涉及转基因前列腺癌和转基因肝癌小鼠模型的临床前研究中，以获得比常规回波平面光谱成像方法更高的空间和时间分辨率。
High polarization of nuclear spins in liquid state through hyperpolarized technology utilizing dynamic nuclear polarization has enabled the direct monitoring of 13C metabolites in vivo at a high signal-to-noise ratio. Acquisition time limitations due to T1 decay of the hyperpolarized signal require accelerated imaging methods, such as compressed sensing, for optimal speed and spatial coverage. In this paper, the design and testing of a new echo-planar 13C three-dimensional magnetic resonance spectroscopic imaging (MRSI) compressed sensing sequence is presented. The sequence provides up to a factor of 7.53 in acceleration with minimal reconstruction artifacts. The key to the design is employing x and y gradient blips during a fly-back readout to pseudorandomly undersample kf-kx-ky space. The design was validated in simulations and phantom experiments where the limits of undersampling and the effects of noise on the compressed sensing nonlinear reconstruction were tested. Finally, this new pulse sequence was applied in vivo in preclinical studies involving transgenic prostate cancer and transgenic liver cancer murine models to obtain much higher spatial and temporal resolution than possible with conventional echo-planar spectroscopic imaging methods.
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影响因子：
3.3
作者：
Chen, Albert P.;Albers, Mark J.;Vigneron, Daniel B.
通讯作者：
Vigneron, Daniel B.
DOI：
10.1007/s10334-009-0169-z
发表时间：
2009-08-01
影响因子：
2.3
作者：
Leupold, Jochen;Mansson, Sven;Wieben, Oliver
通讯作者：
Wieben, Oliver
影响因子：
82.9
作者：
Goga, Andrei;Yang, Dun;Bishop, J. Michael
通讯作者：
Bishop, J. Michael
影响因子：
2.5
作者：
Candès, EJ;Romberg, J;Tao, T
通讯作者：
Tao, T
DOI：
10.1073/pnas.92.8.3439
发表时间：
1995-04-11
影响因子：
11.1
作者：
GREENBERG, NM;DEMAYO, F;ROSEN, JM
通讯作者：
ROSEN, JM