Neurotrophin regulation of ionic currents and cell size depends on cell context.
Neurotrophin regulation of ionic currents and cell size depends on cell context.
复制标题
神经营养素对离子电流和细胞大小的调节取决于细胞环境。
DOI：
10.1073/pnas.94.11.5917
复制
发表时间：
1997
影响因子：
11.1
通讯作者：
Lo,DC
中科院分区：
文献类型：
--
作者：
Sherwood,NT;Lesser,SS;Lo,DC
Trk receptor activation by neurotrophins is often considered to have a defined set of actions on target neurons, including supporting neuronal survival, inducing morphological differentiation, and regulating a host of target genes that specify neuronal phenotype. It is not known if all such regulatory effects are obligatory, or if some may vary depending on the cell context in which the receptors are expressed. We have examined this issue by comparing neurotrophin effects on the regulation of electrical excitability and morphological differentiation in two strains of PC12 cells. We found that while neurotrophins induced neurite extension and increased calcium currents in both PC12 cell types, sodium current levels were regulated in only one of these strains. Moreover, we found little correlation between calcium current levels and the extent of morphological differentiation when compared in individual cells of a single strain. Thus, the regulatory effects of neurotrophins on cell phenotype are not fully determined by the Trk receptors that they activate; rather, they can vary with differences in cell context that arise not only between different cell lineages, but also between individual cells of clonal relation.
登录
查看更多内容
神经生长因子诱导PC12细胞生长锥的形态特性和膜通道
影响因子：
4.2
作者：
P. O'lague;S. Huttner;C. Vandenberg;K. Morrison;R. Horn
通讯作者：
R. Horn
影响因子：
--
作者：
S. Halegoua;R. Armstrong;N. E. Kremer
通讯作者：
S. Halegoua;R. Armstrong;N. E. Kremer
SK-N-SH 神经母细胞瘤细胞中 NGF 和睫状神经营养因子对电压门控离子通道的调节
影响因子：
13.9
作者：
S. Lesser;DC Lo
通讯作者：
DC Lo
神经生长因子在大鼠嗜铬细胞瘤细胞系中两种类型 Ca2+ 通道的差异表达。
DOI：
--
发表时间：
1990
期刊：
Journal of Physiology
影响因子：
--
作者：
M. M. Usowicz;Hartmiut Porzig;C. Becker;H. Reuter
通讯作者：
H. Reuter
享受基因转移带来的乐趣
影响因子：
9.2
作者：
L. Pecorino;D. Lo
通讯作者：
D. Lo