G.I. pros: Antimicrobial defense in the gastrointestinal tract.

G.I. pros: Antimicrobial defense in the gastrointestinal tract.
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DOI:
10.1016/j.semcdb.2018.02.001
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发表时间:
2019-04
影响因子:
7.3
通讯作者:
Raffatellu M
Raffatellu M
中科院分区:
生物学2区
文献类型:
--
作者:
Chung LK;Raffatellu M

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胃肠道是一个复杂的环境,宿主免疫系统与多种微生物相互作用,既有共生微生物,也有致病微生物。因此,根据每种刺激的性质动员快速和适当的抗菌反应对于维持肠道内稳态和炎症之间的平衡至关重要。在这里,我们关注肠道抗菌肽在生态失调和感染期间调节微生物群落的机制。我们还讨论了有助于减少肠道病原体生长的细菌肽类。这篇综述的目的是提供一个全面的概述不同的抗菌反应与肠道病原体和肠道微生物群的相互作用。
The gastrointestinal tract is a complex environment in which the host immune system interacts with a diverse array of microorganisms, both symbiotic and pathogenic. As such, mobilizing a rapid and appropriate antimicrobial response depending on the nature of each stimulus is crucial for maintaining the balance between homeostasis and inflammation in the gut. Here we focus on the mechanisms by which intestinal antimicrobial peptides regulate microbial communities during dysbiosis and infection. We also discuss classes of bacterial peptides that contribute to reducing enteric pathogen outgrowth. This review aims to provide a comprehensive overview on the interplay of diverse antimicrobial responses with enteric pathogens and the gut microbiota.
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