Rapid and reversible inhibition of junctional communication by tumor promoters in a mouse cell line.
Rapid and reversible inhibition of junctional communication by tumor promoters in a mouse cell line.
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小鼠细胞系中肿瘤启动子对连接通讯的快速和可逆抑制。
作者：
Desmond J. Fitzgerald;Knowles Se;Ballard Fj;Murray Aw
HEL-37细胞在接触细胞之间快速转移显微注射的荧光素。这种转移强烈抑制肿瘤促进佛波酯和mezerein，但不是由非促进衍生物。抑制作用的发作发生后5至10分钟的暴露于测试化合物，并在20分钟内完成。使用一个冲洗程序，它表明，抑制染料转移佛波醇-12，13-二丁酸酯完全逆转100分钟后，滞后40至60分钟。染料转移能力的恢复被阻断嘌呤霉素。12-O-十四酰基佛波醇-13-乙酸酯和莫能菌素引起HEL-37细胞中Na+水平升高，但后一种化合物不抑制染料转移。可以得出结论，启动子抑制的转移是不是一个后果Na+诱导的细胞质Ca 2+浓度的增加。
HEL-37 cells rapidly transferred microinjected fluorescein between contacting cells. This transfer was strongly inhibited by tumor-promoting phorbol esters and mezerein but not by non-promoting derivatives. The onset of the inhibition occurred after 5 to 10 min of exposure to the test compound and was complete within 20 min. Using a wash-off procedure, it was demonstrated that inhibition of dye transfer by phorbol-12, 13-dibutyrate was fully reversed by 100 min, after a lag of 40 to 60 min. The recovery of dye transfer competence was blocked by puromycin. Both 12-O-tetradecanoylphorbol-13-acetate and monensin caused elevated Na+ levels in HEL-37 cells, but the latter compound did not inhibit dye transfer. It was concluded that the promoter inhibition of transfer was not a consequence of Na+-induced increase in cytoplasmic Ca2+ concentration.
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影响因子：
--
作者：
Diamond, L;O'Brien, T G;Baird, W M
通讯作者：
Baird, W M
暴露于肿瘤促进剂 12-O-十四烷酰佛波醇-13-乙酸酯后，中国仓鼠 V-79 细胞之间间隙连接的发生率降低。
影响因子：
3.7
作者：
Yancey,SB;Edens,JE;Trosko,JE;Chang,CC;Revel,JP
通讯作者：
Revel,JP
12-O tetradecanoylphorbol-13-acetate 破坏晚期癌前人类结肠上皮细胞之间的通讯。
影响因子：
11.2
作者：
Friedman,EA;Steinberg,M
通讯作者：
Steinberg,M
各种多溴联苯 (PBB) 同系物对培养的中国仓鼠 V79 细胞代谢协同的抑制。
影响因子：
4.7
作者：
Tsushimoto,G;Trosko,JE;Chang,CC;Aust,SD
通讯作者：
Aust,SD
佛波酯刺激预先标记的细胞快速释放胆碱。
影响因子：
4.7
作者：
Mufson,RA;Okin,E;Weinstein,IB
通讯作者：
Weinstein,IB