Childhood adversity is associated with heightened inflammation after sleep loss.
Childhood adversity is associated with heightened inflammation after sleep loss.
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DOI：
10.1016/j.sleh.2022.03.006
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发表时间：
2022-06
期刊：
影响因子：
4.1
通讯作者：
Palmer, Cara A.
中科院分区：
文献类型：
--
作者：
John-Henderson, Neha A.;Kampf, Taylor D.;Alvarado, Giovanni;Counts, Cory J.;Larsen, Jade M.;Palmer, Cara A.
To investigate whether childhood adversity exacerbates the relationship between sleep restriction and inflammation. Participants (N=46) were randomly assigned to an experimental sleep restriction group (n=25) or a night of typical sleep (n=21). Participants provided a dried blood spot sample the morning before and after the experimental night. A significant interaction emerged between childhood adversity and group assignment on C-reactive protein (CRP) after the experimental night (Beta = −.02, SE = .01, p = .03, 95% CI: −.05, −.002). Sleep restriction resulted in an increase in CRP at high levels of childhood adversity (+1 SD; Effect = −.57, SE = .15, p < .001; 95% CI: −.87, −.26) but not low levels of childhood adversity (Effect = −.08, SE = .10, p = .40; 95% CI: −.29, .12). Childhood adversity may amplify the effect of sleep loss on markers of inflammation.
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影响因子：
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