The circular SiZer, inferred persistence of shape parameters and application to early stem cell differentiation.

The circular SiZer, inferred persistence of shape parameters and application to early stem cell differentiation.
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圆形 SiZer,推断形状参数的持久性及其在早期干细胞分化中的应用。

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发表时间:
2014
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通讯作者:
Carina Wollnik
Carina Wollnik
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作者:
S. Huckemann;Kwang;A. Munk;F. Rehfeldt;Max Sommerfeld;J. Weickert;Carina Wollnik

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我们推广了Chaudhuri和Marron(J. Amer. Statistist. Assoc.94(1999)807-823,Ann. Statistist. 28(2000)408-428)用于检测圆形数据情况下的真实的线上的密度的形状参数。事实证明,只有包裹高斯核给出了一个对称的,强Lipschitz半群满足“循环”因果关系,也就是说,不引入可能的人工模式与平滑水平的增加。欧几里德和循环尺度空间理论之间的一些显着差异突出。在此基础上,我们提供了一个渐近理论来推断形状特征的持久性。由此产生的循环模式持久性图应用于分析早期机械诱导分化成人干细胞从他们的肌动蛋白肌球蛋白丝结构。因此,基于包裹的高斯核(WiZer)的圆形SiZer允许在Zemel等人(Nat.Phys.6(2010)468-473)报道的观察的受控误差水平下进行验证:在早期干细胞分化中,干细胞的极化在三种不同的微环境中表现出优选的方向。
We generalize the SiZer of Chaudhuri and Marron (J. Amer. Statist. Assoc. 94 (1999) 807-823, Ann. Statist. 28 (2000) 408-428) for the detection of shape parameters of densities on the real line to the case of circular data. It turns out that only the wrapped Gaussian kernel gives a symmetric, strongly Lipschitz semi-group satisfying "circular" causality, that is, not introducing possibly artificial modes with increasing levels of smoothing. Some notable differences between Euclidean and circular scale space theory are highlighted. Based on this, we provide an asymptotic theory to make inference about the persistence of shape features. The resulting circular mode persistence diagram is applied to the analysis of early mechanically-induced differentiation in adult human stem cells from their actin-myosin filament structure. As a consequence, the circular SiZer based on the wrapped Gaussian kernel (WiZer) allows the verification at a controlled error level of the observation reported by Zemel et al. (Nat. Phys. 6 (2010) 468-473): Within early stem cell differentiation, polarizations of stem cells exhibit preferred directions in three different micro-environments.
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