Real-Time fMRI Functional Connectivity Neurofeedback Reducing Repetitive Negative Thinking in Depression: A Double-Blind, Randomized, Sham-Controlled Proof-of-Concept Trial.
Real-Time fMRI Functional Connectivity Neurofeedback Reducing Repetitive Negative Thinking in Depression: A Double-Blind, Randomized, Sham-Controlled Proof-of-Concept Trial.
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DOI：
10.1159/000528377
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发表时间：
2023
影响因子：
22.8
通讯作者：
Guinjoan, Salvador M.
中科院分区：
文献类型：
--
作者：
Tsuchiyagaito, Aki;Misaki, Masaya;Kirlic, Namik;Yu, Xiaoqian;Sanchez, Stella M.;Cochran, Gabe;Stewart, Jennifer L.;Smith, Ryan;Fitzgerald, Kate D.;Rohan, Michael L.;Paulus, Martin P.;Guinjoan, Salvador M.
重复消极思维（RNT）是一种专注于自我相关和消极经历的认知过程，导致重度抑郁症（MDD）的预后不良。我们之前发现楔前叶/后扣带皮层 (PCC) 和右颞顶交界处 (rTPJ) 之间的连接与 RNT 水平呈正相关。在这项双盲、随机、假对照、概念验证试验中，我们采用实时功能磁共振成像神经反馈 (rtfMRI-nf) 来描绘可能与 RNT 存在因果关系并可能成为 MDD 治疗目标的神经过程。受 MDD 影响的个体被分配到主动反馈组 (n = 20) 或假反馈组 (n = 19)。在干预前和干预后 1 周，通过反刍反应量表-育雏子量表 (RRS-B) 测量 RNT。活跃组而非假手术组的个体的 RRS-B 显着降低；然而，PCC-rTPJ 连接性的大幅减少与 RRS-B 的大幅减少无关。探索性分析显示，在活动组中，压后皮层 (RSC)-rTPJ 连接的更大程度减少导致 RRS-B 更明显减少，但在假手术组中则不然。 RtfMRI-nf 可有效降低 RNT。考虑到 rtfMIR-nf 的底层机制，RSC 和 rTPJ 可能是网络（即默认模式网络）的一部分，可能共同影响 RNT 的强度。了解目标神经变化的功能组织与 RNT 等临床指标之间的关系，有可能指导基于机制的 MDD 治疗的发展。
Repetitive negative thinking (RNT) is a cognitive process focusing on self-relevant and negative experiences, leading to a poor prognosis of major depressive disorder (MDD). We previously identified that connectivity between the precuneus/posterior cingulate cortex (PCC) and right temporoparietal junction (rTPJ) was positively correlated with levels of RNT. In this double-blind, randomized, sham-controlled, proof-of-concept trial, we employed real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) to delineate the neural processes that may be causally linked to RNT and could potentially become treatment targets for MDD. MDD-affected individuals were assigned to either active (n = 20) or sham feedback group (n = 19). RNT was measured by the Ruminative Response Scale-brooding subscale (RRS-B) before and 1 week after the intervention. Individuals in the active but not in the sham group showed a significant reduction in the RRS-B; however, a greater reduction in the PCC-rTPJ connectivity was unrelated to a greater reduction in the RRS-B. Exploratory analyses revealed that a greater reduction in the retrosplenial cortex (RSC)-rTPJ connectivity yielded a more pronounced reduction in the RRS-B in the active but not in the sham group. RtfMRI-nf was effective in reducing RNT. Considering the underlying mechanism of rtfMIR-nf, the RSC and rTPJ could be part of a network (i.e., default mode network) that might collectively affect the intensity of RNT. Understanding the relationship between the functional organization of targeted neural changes and clinical metrics, such as RNT, has the potential to guide the development of mechanism-based treatment of MDD.
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影响因子：
16.2
作者：
Cowansage, Kiriana K.;Shuman, Tristan;Dillingham, Blythe C.;Chang, Allene;Golshani, Peyman;Mayford, Mark
通讯作者：
Mayford, Mark
影响因子：
3.7
作者：
Bessette, Katie L.;Jacobs, Rachel H.;Langenecker, Scott A.
通讯作者：
Langenecker, Scott A.
影响因子：
14.5
作者：
FLETCHER, PC;FRITH, CD;DOLAN, RJ
通讯作者：
DOLAN, RJ
影响因子：
5.9
作者：
JACOBSON, NS;TRUAX, P
通讯作者：
TRUAX, P
影响因子：
22.8
作者：
Guidi, Jenny;Brakemeier, Eva-Lotta;Fava, Giovanni A.
通讯作者：
Fava, Giovanni A.