Direct reactivation of a coherent neocortical memory of context.
Direct reactivation of a coherent neocortical memory of context.
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DOI：
10.1016/j.neuron.2014.09.022
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发表时间：
2014-10-22
期刊：
影响因子：
16.2
通讯作者：
Mayford, Mark
中科院分区：
文献类型：
--
作者：
Cowansage, Kiriana K.;Shuman, Tristan;Dillingham, Blythe C.;Chang, Allene;Golshani, Peyman;Mayford, Mark
陈述性记忆被认为存储在解剖学上分布的神经元网络中，需要海马体;然而，目前还不清楚新皮层区域在编码时如何参与记忆。在这里，我们使用一个c-fos为基础的遗传标记系统，选择性地表达channelrhodopsin的变体，ChEF，和optogenetically重新激活特定的神经合奏在压后皮质（RSC）从事的上下文恐惧条件反射。RSC的人工刺激足以产生与自然经验相称的特定于背景的行为和下游细胞活动。此外，光遗传学，但不是上下文引起的反应是不敏感的海马失活，这表明，虽然海马是需要协调激活的感觉线索，一个高阶皮层框架可以独立地辅助学习行为，即使在学习后不久。
Declarative memories are thought to be stored within anatomically distributed neuronal networks requiring the hippocampus; however, it is unclear how neocortical areas participate in memory at the time of encoding. Here, we use a c-fos-based genetic tagging system to selectively express the channelrhodopsin variant, ChEF, and optogenetically reactivate a specific neural ensemble in retrosplenial cortex (RSC) engaged by context fear conditioning. Artificial stimulation of RSC was sufficient to produce both context-specific behavior and downstream cellular activity commensurate with natural experience. Moreover, optogenetically, but not contextually-elicited responses were insensitive to hippocampal inactivation, suggesting that although the hippocampus is needed to coordinate activation by sensory cues, a higher-order cortical framework can independently subserve learned behavior, even shortly after learning.
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影响因子：
1.9
作者：
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通讯作者：
Bucci, David J.
影响因子：
56.9
作者：
Frankland, PW;Bontempi, B;Silva, AJ
通讯作者：
Silva, AJ
影响因子：
1.9
作者：
Cho, JW;Sharp, PE
通讯作者：
Sharp, PE
影响因子：
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作者：
Amaral, Olavo B.;Luft, Tatiana;Roesler, Rafael
通讯作者：
Roesler, Rafael
DOI：
10.1523/jneurosci.2107-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Corcoran KA;Donnan MD;Tronson NC;Guzmán YF;Gao C;Jovasevic V;Guedea AL;Radulovic J
通讯作者：
Radulovic J