Functional dissociation of the inferior frontal junction from the dorsal attention network in top-down attentional control.
Functional dissociation of the inferior frontal junction from the dorsal attention network in top-down attentional control.
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自上而下的注意力控制中额下交界与背侧注意力网络的功能分离。
DOI：
10.1152/jn.00506.2018
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发表时间：
2018
影响因子：
2.5
通讯作者：
Marois,René
中科院分区：
文献类型：
--
作者：
Tamber-Rosenau,BenjaminJ;Asplund,ChristopherL;Marois,René
后外侧前额叶皮质——特别是下额叶交界处（IFJ）——被认为在注意力的控制中发挥着关键作用。然而，该角色的确切性质仍然难以捉摸。在视觉空间注意力的自愿部署和维持过程中，IFJ 通常与由额眼区和上顶叶皮层组成的核心背侧网络共同激活。在刺激驱动的注意力过程中，IFJ 相反与腹外侧网络耦合，这表明 IFJ 在注意力中发挥着与背侧网络不同的作用。由于 IFJ 会快速切换激活模式以适应目标导向和刺激驱动的注意力条件（Asplund CL、Todd JJ、Snyder AP、Marois R.Nat Neurosci13：507-512，2010），因此我们假设 IFJ 的主要作用是动态重新配置注意力，而不是在稳态条件下维持注意力。该假设预测，在目标导向的视觉空间提示范式中，IFJ 会暂时将注意力集中到提示位置，而背侧注意力网络将在提示和目标呈现之间的延迟期间保持注意力权重。在这里，我们用功能磁共振成像测试了这一假设，同时受试者参与具有可变提示目标延迟的波斯纳提示任务。 IFJ 和背侧网络区域都参与瞬时过程，但背侧网络的持续活动比 IFJ 明显得多。这些结果支持这样的观点：IFJ 主要用于转移注意力，而背侧网络是维持稳定注意力状态的主要场所。新的和值得注意的目标导向的视觉空间注意力由背侧额顶叶网络和外侧前额叶皮层控制。然而，这些区域在目标导向注意力中的相对作用尚不清楚。在这里，我们提供了它们在注意力设置的短暂重新配置和持续维持中的分离作用的证据：虽然注意力设置的维持仅限于背侧网络，但在注意力发作开始时这些设置的配置是外侧前额叶皮层的功能。
The posterior lateral prefrontal cortex—specifically, the inferior frontal junction (IFJ)—is thought to exert a key role in the control of attention. However, the precise nature of that role remains elusive. During the voluntary deployment and maintenance of visuospatial attention, the IFJ is typically coactivated with a core dorsal network consisting of the frontal eye field and superior parietal cortex. During stimulus-driven attention, IFJ instead couples with a ventrolateral network, suggesting that IFJ plays a role in attention distinct from the dorsal network. Because IFJ rapidly switches activation patterns to accommodate conditions of goal-directed and stimulus-driven attention (Asplund CL, Todd JJ, Snyder AP, Marois R.Nat Neurosci13: 507–512, 2010), we hypothesized that IFJ’s primary role is to dynamically reconfigure attention rather than to maintain attention under steady-state conditions. This hypothesis predicts that in a goal-directed visuospatial cuing paradigm IFJ would transiently deploy attention toward the cued location, whereas the dorsal attention network would maintain attentional weights during the delay between cue and target presentation. Here we tested this hypothesis with functional magnetic resonance imaging while subjects were engaged in a Posner cuing task with variable cue-target delays. Both IFJ and dorsal network regions were involved in transient processes, but sustained activity was far more evident in the dorsal network than in IFJ. These results support the account that IFJ primarily acts to shift attention whereas the dorsal network is the main locus for the maintenance of stable attentional states.NEW & NOTEWORTHYGoal-directed visuospatial attention is controlled by a dorsal fronto-parietal network and lateral prefrontal cortex. However, the relative roles of these regions in goal-directed attention are unknown. Here we present evidence for their dissociable roles in the transient reconfiguration and sustained maintenance of attentional settings: while maintenance of attentional settings is confined to the dorsal network, the configuration of these settings at the beginning of an attentional episode is a function of lateral prefrontal cortex.
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--
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