Acetic acid stress in budding yeast: From molecular mechanisms to applications.
Acetic acid stress in budding yeast: From molecular mechanisms to applications.
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DOI：
10.1002/yea.3651
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Bettiga M
中科院分区：
文献类型：
--
作者：
Guaragnella N;Bettiga M
乙酸应激是酵母细胞在多种环境条件和工业生物过程中经常面临的挑战。其反应背后的分子机制已在芽殖酵母酿酒酵母中得到了大部分阐明，其中乙酸可以是生理底物或应激源。本综述将重点关注乙酸应激及其在细胞运输、pH 稳态、代谢和应激信号通路背景下的反应。这些信息已与多组学、合成生物学和代谢工程方法获得的结果相结合，旨在确定参与醋酸耐受的主要细胞参与者。在利用木质纤维素生物质生产生物燃料和可再生化学品时，提高醋酸耐受性是一个关键因素。从这个角度来看，还将讨论如何利用这些知识来促进酵母细胞工厂可持续应用的发展和竞争力。乙酸胁迫是芽殖酵母经常面临的挑战。信号通路剖析和全系统方法揭示了一幅复杂的图景。酸性胁迫条件下的细胞适应性和适应取决于环境。对乙酸的耐受性是基于酵母的工业生物技术的一个关键因素。没有“灵丹妙药”：综合方法有利于开发高性能酵母细胞工厂。多种因素影响出芽酵母酿酒酵母的乙酸胁迫和耐受性。
Acetic acid stress represents a frequent challenge to counteract for yeast cells under several environmental conditions and industrial bioprocesses. The molecular mechanisms underlying its response have been mostly elucidated in the budding yeast Saccharomyces cerevisiae, where acetic acid can be either a physiological substrate or a stressor. This review will focus on acetic acid stress and its response in the context of cellular transport, pH homeostasis, metabolism and stress‐signalling pathways. This information has been integrated with the results obtained by multi‐omics, synthetic biology and metabolic engineering approaches aimed to identify major cellular players involved in acetic acid tolerance. In the production of biofuels and renewable chemicals from lignocellulosic biomass, the improvement of acetic acid tolerance is a key factor. In this view, how this knowledge could be used to contribute to the development and competitiveness of yeast cell factories for sustainable applications will be also discussed. Acetic acid stress is a frequent challenge for budding yeast. Signalling pathways dissection and system‐wide approaches reveal a complex picture. Cell fitness and adaptation under acid stress conditions is environment dependent. Tolerance to acetic acid is a key factor in yeast‐based industrial biotechnology. There is no ‘magic bullet’: An integrated approach is advantageous to develop performing yeast cell factories. Multiple factors influenced acetic acid stress and tolerance in the budding yeast Saccharomyces cerevisiae.
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