Leaves of Magnolia liliflora Desr. as a high-potential by-product: Lignans composition, antioxidant, anti-inflammatory, anti-phytopathogenic fungal and phytotoxic activities
Leaves of Magnolia liliflora Desr. as a high-potential by-product: Lignans composition, antioxidant, anti-inflammatory, anti-phytopathogenic fungal and phytotoxic activities
复制标题
紫玉兰 Desr 的叶子。
DOI：
10.1016/j.indcrop.2018.09.023
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发表时间：
2018-12
影响因子：
5.9
通讯作者：
Chen Xue
中科院分区：
文献类型：
--
作者：
Wu Hai-bo;Liu Ting-ting;Zhang Zheng-xi;Wang Wen-shu;Zhu Wen-wen;Li Lin-feng;Li Yu-rong;Chen Xue
收获白玉兰花蕾后。（传统中医称为“信义”），大量的m。副产物为百合花叶。本研究的目的是验证MLL的潜在用途，并分离其具有抗氧化、抗炎、抗真菌和植物毒性活性的生物活性化合物。木脂素含量和抗氧化活性最高的木脂素乙醇提取液乙酸乙酯提取物（ETE）得到了4个新木脂素（1 ~ 4）和15个已知木脂素（5 ~ 19），具有良好的应用价值。基于一维和二维核磁共振数据和hresms数据解释，确定了木脂素的结构。化合物2、9和10通过DPPH、ABTS和FRAP检测显示具有抗氧化活性。与阳性对照吲哚美辛相比，化合物2 - 3、9 - 11和13 - 14具有明显的抗炎活性。化合物9、11和19对3种具有重要农业经济价值的植物病原菌（禾谷镰刀菌、稻瘟病菌、alternnaria alternata）均有抑制作用，MIC值在32 ~ 128 μg/mL之间。化合物5和11对生菜幼苗的EC50分别为0.37和0.95 mM。结果表明，MLL可作为一种有前途的高潜力的副产物和廉价的木脂素来源，用于制药、食品和农业工业。
After harvesting the flower buds ofMagnolia lilifloraDesr. (the traditional Chinese medicine known as “Xinyi”), a significant quantity ofM. lilifloraleaf (MLL) was generated as a by-product. The aim of this study is to verify the potential use of MLL and isolate its bioactive compounds with antioxidant, anti-inflammatory, antifungal and phytotoxic activities. The ethyl acetate extract (ETE) from ethanol extract of MLL with the highest lignan content and antioxidant activity showed a good application value, from which four new lignans (1–4) along with fifteen known lignans (5–19) were isolated. The structures of lignans were established on the basis of 1D and 2D NMR data and HRESIMS data interpretation. Compounds2,9and10exhibited antioxidant activities as assessed by DPPH, ABTS and FRAP methods. Compounds2–3,9–11and13–14showed pronounced anti-inflammatory activities compared with positive control indomethacin. Compounds9,11and19showed antifungal effects on three plant pathogens of economic importance in agriculture (Fusarium graminearum,Pyricularia oryzae,Alternaria alternata) with MIC values ranging from 32 to 128 μg/mL. Compounds5and11showed an inhibitory effect on lettuce shoots with EC50= 0.37 and 0.95 mM, respectively. The results indicated that MLL could be regarded as a promising high-potential by-product and inexpensive source of lignans for the pharmaceutical, food and agricultural industries.
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影响因子：
5.1
作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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