Effects of depression on employment and social outcomes: a Mendelian randomisation study.
Effects of depression on employment and social outcomes: a Mendelian randomisation study.
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DOI：
10.1136/jech-2021-218074
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发表时间：
2022-06
影响因子：
6.3
通讯作者：
Katikireddi, Srinivasa Vittal
中科院分区：
文献类型：
--
作者：
Campbell, Desmond;Green, Michael James;Davies, Neil;Demou, Evangelia;Howe, Laura D.;Harrison, Sean;Smith, Daniel J.;Howard, David M.;McIntosh, Andrew M.;Munafo, Marcus;Katikireddi, Srinivasa Vittal
关键词：
抑郁症与社会经济劣势有关。然而，抑郁症是否以及如何对就业产生因果影响仍不清楚。我们使用孟德尔随机化 (MR) 来研究抑郁症是否影响英国生物银行数据集中的就业和相关结果。我们在英国生物银行研究中选择了 227~242 名具有适当遗传数据的英国白人/血统的工作年龄参与者（男性 40-64 岁，女性 40-59 岁）。我们使用 30 个与抑郁症相关的独立遗传变异作为工具。我们进行了观察性和双样本 MR 分析。结果是就业状况（就业与失业、就业与疾病/残疾、失业、退休或照顾家庭/家人）；每周工作时间（受雇者）；汤森剥夺指数；最高教育程度；和家庭收入。经历过抑郁症的人失业、生病/残疾、失业、照顾家庭和提前退休的几率更高。抑郁症与每周工作时间减少、家庭收入降低、教育程度降低以及贫困加剧有关。 MR 分析表明，抑郁倾向导致失业（OR 1.16，95%CI 1.06 至 1.26）和疾病/残疾（OR 1.56，95%CI 1.34 至 1.82）增加，但与照顾家庭、提前退休或失业无关。 MR 几乎没有证据表明抑郁症会影响每周工作时间、教育程度、家庭收入或贫困。抑郁症责任似乎会导致失业增加，特别是残疾增加。几乎没有证据表明抑郁症会影响提前退休、工作时间或家庭收入，但权力很低。抑郁症的有效治疗可能会给个人和社会带来重要的经济效益。
Depression is associated with socioeconomic disadvantage. However, whether and how depression exerts a causal effect on employment remains unclear. We used Mendelian randomisation (MR) to investigate whether depression affects employment and related outcomes in the UK Biobank dataset. We selected 227 242 working-age participants (40–64 in men, 40–59 years for women) of white British ethnicity/ancestry with suitable genetic data in the UK Biobank study. We used 30 independent genetic variants associated with depression as instruments. We conducted observational and two-sample MR analyses. Outcomes were employment status (employed vs not, and employed vs sickness/disability, unemployment, retirement or caring for home/family); weekly hours worked (among employed); Townsend Deprivation Index; highest educational attainment; and household income. People who had experienced depression had higher odds of non-employment, sickness/disability, unemployment, caring for home/family and early retirement. Depression was associated with reduced weekly hours worked, lower household income and lower educational attainment, and increased deprivation. MR analyses suggested depression liability caused increased non-employment (OR 1.16, 95% CI 1.06 to 1.26) and sickness/disability (OR 1.56, 95% CI 1.34 to 1.82), but was not causal for caring for home/family, early retirement or unemployment. There was little evidence from MR that depression affected weekly hours worked, educational attainment, household income or deprivation. Depression liability appears to cause increased non-employment, particularly by increasing disability. There was little evidence of depression affecting early retirement, hours worked or household income, but power was low. Effective treatment of depression might have important economic benefits to individuals and society.
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影响因子：
7.7
作者：
Bowden J;Del Greco M F;Minelli C;Davey Smith G;Sheehan NA;Thompson JR
通讯作者：
Thompson JR
影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
影响因子：
5
作者：
Fry A;Littlejohns TJ;Sudlow C;Doherty N;Adamska L;Sprosen T;Collins R;Allen NE
通讯作者：
Allen NE
影响因子：
2.1
作者：
Bowden J;Davey Smith G;Haycock PC;Burgess S
通讯作者：
Burgess S
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ