A biomechanical model for evaluating the performance of accommodative intraocular lenses.
A biomechanical model for evaluating the performance of accommodative intraocular lenses.
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DOI：
10.1016/j.jbiomech.2022.111054
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发表时间：
2022-05
影响因子：
2.4
通讯作者：
Pedrigi RM
中科院分区：
文献类型：
--
作者：
Ameku KA;Pedrigi RM
调节改变眼睛晶状体的形状，将焦点从远视力改变为近视力。在老花眼发展过程中，这种功能随着年龄的增长而下降，大多数人在 55 岁时几乎完全丧失调节能力。目前，还没有矫正老花眼的手术方法，但在白内障手术期间植入的可调节人工晶状体（AIOL）的开发方面已经做了相当多的工作。尽管做出了这些努力，AIOL 只能恢复约 20% 的年轻调节幅度，而且它们患有导致视觉衰弱的纤维化的比例很高。建模是目前缺乏的一个有助于改进 AIOL 设计的重要设计工具。在此，我们通过开发全 3D 有限元模型来满足这一需求，该模型用于预测植入术后晶状体囊内的双光学 AIOL 的行为。开发了天然人类晶状体模型，以确定准确预测晶状体调节状态所需的晶状体囊的无应力配置以及未调节状态所需的小带牵引配置。 AIOL 模型证明了植入物刚度的功能重要性，并预测了小带牵引力大小和光学器件轴向位移之间的近似线性关系。据我们所知，这是第一个可用于深入了解 AIOL 功效的模型。它为持续开发预测工具奠定了基础，最终可以改进旨在恢复年轻调节功能的 AIOL 设计。
Accommodation alters the shape of the eye lens to change focus from distant to near vision. This function declines with age in the development of presbyopia and most people experience a near total loss of accommodative ability by 55 years. Currently, there are no surgical procedures that correct presbyopia, but considerable work has been done in the development of accommodative intraocular lenses (AIOLs) implanted during cataract surgery. Despite these efforts, AIOLs only restore ~20% of youthful accommodative amplitude and they suffer from high rates of visually-debilitating fibrosis. An important design tool that is lacking that could aid in improving AIOL designs is modeling. Herein, we addressed this need through the development of a fully 3-D finite element model that was used to predict the behavior of a dual-optic AIOL implanted within the post-surgical lens capsule. Models of the native human lens were developed to identify the stress-free configuration of the lens capsule needed to accurately predict the accommodated state of the lens and the configuration of the zonular traction needed for the disaccommodated state. The AIOL model demonstrated the functional importance of implant stiffness and predicted an approximately linear relationship between zonular traction magnitude and axial displacement of the optics. To our knowledge, this is the first model that can be used to gain insights into AIOL efficacy. It provides a foundation for continued development of a predictive tool that could ultimately improve AIOL designs that seek to restore youthful accommodative function.
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影响因子：
3.5
作者：
Burd, Harvey John
通讯作者：
Burd, Harvey John
DOI：
10.1080/10255842.2016.1228907
发表时间：
2017-01-01
影响因子：
1.6
作者：
David, G.;Pedrigi, R. M.;Humphrey, J. D.
通讯作者：
Humphrey, J. D.
影响因子：
1.8
作者：
Hermans, E. A.;Dubbelman, M.;Heethaar, R. M.
通讯作者：
Heethaar, R. M.
影响因子：
1.8
作者：
Dubbelman, M;Van der Heijde, GL
通讯作者：
Van der Heijde, GL
影响因子：
1.8
作者：
Hermans, E. A.;Dubbelman, M.;Heethaar, R. M.
通讯作者：
Heethaar, R. M.