Impact of leptin deficiency on male tibia and vertebral body 3D bone architecture independent of changes in body weight.
Impact of leptin deficiency on male tibia and vertebral body 3D bone architecture independent of changes in body weight.
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DOI：
10.14814/phy2.15832
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发表时间：
2023-10
影响因子：
2.5
通讯作者：
中科院分区：
文献类型：
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作者：
瘦素是一种脂肪因子，对能量平衡和体重有重要影响，在哺乳动物生长期的骨结构中起着重要作用。然而，体重的重大变化也会影响骨小梁和皮质骨的形态。因此，我们研究了瘦素缺乏对胫骨和椎体3D骨结构的影响，与体重变化无关。此外，计算3D图像分析的进展表明，平均形态值可能掩盖骨小梁厚度的区域特异性差异。该研究使用瘦素缺乏的Ob/Ob小鼠（n = 8）与C57 BL/6（C57）对照小鼠（n = 8）配对，将其分为瘦或肥胖组，持续24 ± 2周。在进行高分辨率微型计算机断层扫描（μCT）之前，固定整个胫骨和L3椎骨。与体重无关的瘦素缺乏减少了胫骨皮质骨体积、骨小梁体积/组织体积、数量和矿物质密度。平均胫骨骨小梁厚度显示所有组之间无显著差异;然而，按区域分析时发现骨小梁厚度有显著变化。这项研究表明，瘦素缺乏显着影响胫骨和椎体骨小梁和皮质骨的三维结构独立于体重的变化。
Leptin an adipokine with potent effects on energy balance and body weight plays an important role in defining bone architecture in growing mammals. However, major changes in body weight can also influence morphology of trabecular and cortical bone. Therefore, we examined the impact of leptin deficiency on tibia and vertebral body 3D bone architecture independent of changes in body weight. Furthermore, advances in computational 3D image analysis suggest that average morphological values may mask regional specific differences in trabecular bone thickness. The study utilized leptin‐deficient Ob/Ob mice (n = 8) weight‐paired to C57BL/6 (C57) control mice (n = 8) which were split into either lean or obese groups for 24 ± 2 weeks. Whole tibias and L3 vertebrae were fixed before high resolution microcomputed tomography (μCT) scanning was performed. Leptin deficiency independent of body weight reduced tibia cortical bone volume, trabecular bone volume/tissue volume, number, and mineral density. Mean tibia trabecular thickness showed no significant differences between all groups; however, significant changes in trabecular thickness were found when analyzed by region. This study demonstrates that leptin deficiency significantly impacts tibia and vertebral body trabecular and cortical bone 3D architecture independent of changes in body weight.
脂肪质量百分比与中国青少年农村青少年的骨骼质量和髋关节几何形状成反比。
DOI：
10.1002/jbmr.40
发表时间：
2010-07
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Hong X;Arguelles LM;Liu X;Tsai HJ;Hsu YH;Wang B;Zhang S;Li Z;Tang G;Liu X;Yang J;Xu X;Langman C;Wang X
通讯作者：
Wang X
影响因子：
4.6
作者：
do Carmo, Jussara M.;da Silva, Alexandre A.;Dubinion, John;Sessums, Price O.;Ebaady, Sabira H.;Wang, Zhen;Hall, John E.
通讯作者：
Hall, John E.
影响因子：
3.7
作者：
Skowronski AA;Ravussin Y;Leibel RL;LeDuc CA
通讯作者：
LeDuc CA