Low serum amylase in association with metabolic syndrome and diabetes: A community-based study.
Low serum amylase in association with metabolic syndrome and diabetes: A community-based study.
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DOI：
10.1186/1475-2840-10-34
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发表时间：
2011-04-17
影响因子：
9.3
通讯作者：
Munakata H
中科院分区：
文献类型：
--
作者：
Nakajima K;Nemoto T;Muneyuki T;Kakei M;Fuchigami H;Munakata H
低血清淀粉酶水平可能反映胰腺外分泌-内分泌关系受损。然而，很少有临床研究解决了这个问题。因此，在这项流行病学研究中，我们调查了低血清淀粉酶是否与胰岛素作用受损的发病机制相关：代谢综合征（MetS）和糖尿病。对最近（2009年4月至2010年3月）和5年前接受体检的2，425名年龄在30-80岁之间的无症状受试者进行了血清淀粉酶、心脏代谢危险因素、MetS（成人治疗小组III标准）和糖尿病检查。除年龄和估计肾小球滤过率（eGFR）外，临床变量随着血清淀粉酶水平的升高而有利地变化。随着血清淀粉酶水平的降低，OGTT期间1小时和2小时的血糖水平显著升高。多因素logistic分析显示，与血清淀粉酶最高四分位数相比，校正混杂因素后，最低四分位数与代谢综合征和糖尿病风险增加相关[比值比（95%CI）分别为2.07（1.39-3.07）和2.76（1.49-5.11）]。在5年前接受检查的受试者中（n = 571），前一次检查时淀粉酶较低与最近一次检查时代谢异常数量较多相关。在既往检查时血清淀粉酶水平低的受试者中，血清淀粉酶水平随时间的波动轻微，不受肾功能不全的影响。我们的研究结果表明，低血清淀粉酶与代谢异常，代谢综合征和糖尿病的风险增加。这些结果表明，在某些临床条件下，胰腺外分泌-内分泌的关系。
Low serum amylase levels may reflect impaired exocrine-endocrine relationship in the pancreas. However, few clinical studies have addressed this issue. Therefore, in this epidemiological study, we investigated whether low serum amylase was associated with the pathogenesis of impaired insulin action: metabolic syndrome (MetS) and diabetes. Serum amylase, cardiometabolic risk factors, MetS (Adult Treatment Panel III criteria), and diabetes were examined in 2,425 asymptomatic subjects aged 30-80 years who underwent medical checkups recently (April 2009-March 2010) and 5 years ago. Clinical variables, except for age and estimated glomerular filtration rate (eGFR), shifted favorably with increasing serum amylase levels. Plasma glucose levels at 1- and 2-hr during OGTT increased significantly with decreasing serum amylase levels. Multiple logistic analyses showed that, compared with highest quartile of serum amylase, lowest quartile was associated with increased risk for MetS and diabetes after adjustment for confounding factors [odds ratio (95% CI), 2.07 (1.39-3.07) and 2.76 (1.49-5.11), respectively]. In subjects who underwent checkups 5 years ago (n = 571), lower amylase at the previous checkup were associated with larger numbers of metabolic abnormalities at the recent checkup. The fluctuation over time in serum amylase levels in subjects with low serum amylase at the previous checkup was slight and was unaffected by kidney dysfunction. Our results indicate that low serum amylase is associated with increased risk of metabolic abnormalities, MetS and diabetes. These results suggest a pancreatic exocrine-endocrine relationship in certain clinical conditions.
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2型糖尿病中内分泌 - 分泌胰腺传播的衰减：胰腺外基质基质超微结构异常。
DOI：
10.1111/j.1559-4572.2008.00024.x
发表时间：
2008
期刊：
Journal of the cardiometabolic syndrome
影响因子：
--
作者：
Hayden MR;Patel K;Habibi J;Gupta D;Tekwani SS;Whaley-Connell A;Sowers JR
通讯作者：
Sowers JR
影响因子：
7.7
作者：
FARESE, RV;LARSON, RE;SABIR, MA
通讯作者：
SABIR, MA
影响因子：
8.2
作者：
FRIER, BM;FABER, OK;ELLIOTT, HL
通讯作者：
ELLIOTT, HL
DOI：
10.1161/01.atv.14.12.1946
发表时间：
1994-12-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
ELIASSON, B;ATTVALL, S;SMITH, U
通讯作者：
SMITH, U
影响因子：
13.2
作者：
Matsuo, Seiichi;Imai, Enyu;Hishida, Akira
通讯作者：
Hishida, Akira