Prospects for chimeric antigen receptor (CAR) γδ T cells: A potential game changer for adoptive T cell cancer immunotherapy.
Prospects for chimeric antigen receptor (CAR) γδ T cells: A potential game changer for adoptive T cell cancer immunotherapy.
复制标题
DOI：
10.1016/j.canlet.2016.07.001
复制
发表时间：
2016-10-01
期刊：
影响因子：
9.7
通讯作者：
Till, Brian G.
中科院分区：
文献类型：
--
作者：
Mirzaei, Hamid Reza;Mirzaei, Hamed;Lee, Sang Yun;Hadjati, Jamshid;Till, Brian G.
人们对利用患者免疫系统的力量来对抗疾病的疗法越来越兴奋。免疫疗法的一种方法是改造患者自身的T细胞，使其表达一种嵌合抗原受体（CAR），以治疗晚期癌症，特别是那些对传统治疗药物难治的癌症。尽管这些工程免疫细胞在治疗某些血液系统恶性肿瘤方面取得了显著进展，但在实体肿瘤方面的成功仍然有限，可能是由于肿瘤生态位的免疫抑制机制。在迄今为止几乎所有的研究中，携带αβ受体的T细胞都被用来产生CAR - T细胞。在这篇综述中，我们强调了γδ T细胞不同于αβ T细胞的生物学特性，包括归巢上皮和粘膜组织，以及独特的功能，如直接抗原识别，缺乏同种异体反应性和递呈抗原的能力。我们的观点是，这些特征使得γδ T细胞有望用于多种类型实体瘤的细胞治疗，包括黑色素瘤和胃肠道癌症。工程化γδ T细胞可作为过继性T细胞治疗粘膜肿瘤的新平台。
Excitement is growing for therapies that harness the power of patients’ immune systems to combat their diseases. One approach to immunotherapy involves engineering patients’ own T cells to express a chimeric antigen receptor (CAR), to treat advanced cancers, particularly those refractory to conventional therapeutic agents. Although these engineered immune cells have made remarkable strides in the treatment of patients with certain hematologic malignancies, success with solid tumors has been limited, probably due to immunosuppressive mechanisms in the tumor niche. In nearly all studies to date, T cells bearing αβ receptors have been used to generate CAR T cells. In this review, we highlight biological characteristics of γδ T cells that are distinct from those of αβ T cells, including homing to epithelial and mucosal tissues and unique functions such as direct antigen recognition, lack of alloreactivity, and ability to present antigens. We offer our perspective that these features make γδ T cells promising for use in cellular therapy against several types of solid tumors, including melanoma and gastrointestinal cancers. Engineered γδ T cells should be considered as a new platform for adoptive T cell cancer therapy for mucosal tumors.
登录
查看更多内容
影响因子：
4.4
作者：
Ali, Zahida;Shao, Lingyan;Chen, Zheng W.
通讯作者：
Chen, Zheng W.
影响因子：
17.1
作者：
Brentjens RJ;Davila ML;Riviere I;Park J;Wang X;Cowell LG;Bartido S;Stefanski J;Taylor C;Olszewska M;Borquez-Ojeda O;Qu J;Wasielewska T;He Q;Bernal Y;Rijo IV;Hedvat C;Kobos R;Curran K;Steinherz P;Jurcic J;Rosenblat T;Maslak P;Frattini M;Sadelain M
通讯作者：
Sadelain M
影响因子：
10.5
作者：
CARDING, SR;KYES, S;HAYDAY, AC
通讯作者：
HAYDAY, AC
影响因子：
4.4
作者：
Corvaisier, M;Moreau-Aubry, A;Jotereau, F
通讯作者：
Jotereau, F
DOI：
10.1084/jem.177.2.475
发表时间：
1993-02-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Carding SR;Allan W;McMickle A;Doherty PC
通讯作者：
Doherty PC