Distinct T cell polyfunctional profile in SARS-CoV-2 seronegative children associated with endemic human coronavirus cross-reactivity.
Distinct T cell polyfunctional profile in SARS-CoV-2 seronegative children associated with endemic human coronavirus cross-reactivity.
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SARS-CoV-2血清阴性儿童中与地方性人类冠状病毒交叉反应相关的不同T细胞多功能谱
DOI：
10.1016/j.isci.2023.108728
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发表时间：
2024-01-19
期刊：
影响因子：
5.8
通讯作者：
Keeton, Roanne S.
中科院分区：
文献类型：
--
作者：
Benede, Ntombi;Tincho, Marius B.;Walters, Avril;Subbiah, Vennesa;Ngomti, Amkele;Baguma, Richard;Butters, Claire;Hahnle, Lina;Mennen, Mathilda;Skelem, Sango;Adriaanse, Marguerite;Facey-Thomas, Heidi;Scott, Christiaan;Day, Jonathan;Spracklen, Timothy F.;van Graan, Strauss;Balla, Sashkia R.;Moyo-Gwete, Thandeka;Moore, Penny L.;MacGinty, Rae;Botha, Maresa;Workman, Lesley;Johnson, Marina;Goldblatt, David;Zar, Heather J.;Ntusi, Ntobeko A. B.;Zuhlke, Liesl;Webb, Kate;Riou, Catherin;Burgers, Wendy A.;Keeton, Roanne S.
儿童SARS-CoV-2感染通常导致无症状或轻度疾病。关于非洲儿童SARS-CoV-2抗病毒免疫的研究很少。我们调查了71名未接种疫苗的南非无症状儿童的SARS-CoV-2特异性T细胞应答，这些儿童对SARS-CoV-2呈血清阳性或血清阴性。SARS-CoV-2特异性CD 4 + T细胞反应在83%的血清阳性和60%的血清阴性儿童中可检测到。虽然两组之间CD 4 + T细胞反应的幅度没有显著差异，但它们的功能特征是不同的，与血清阴性的对应物相比，SARS-CoV-2血清阳性的儿童表现出更高比例的多功能T细胞。血清阴性儿童中SARS-CoV-2特异性CD 4 + T细胞的频率与地方性人冠状病毒（HCoV）HKU 1 IgG应答相关。总的来说，血清阴性儿童中SARS-CoV-2反应性T细胞的存在可能是由于对地方性冠状病毒的交叉反应，并可能有助于在SARS-CoV-2感染儿童中观察到的疾病的相对保护。在60%的血清阴性儿童中检测到SARS-CoV-2特异性T细胞应答血清阳性儿童和血清阴性儿童之间的T细胞应答强度相似血清阴性儿童表现出较低比例的多功能T细胞CoV-2特异性T细胞和地方性HKU 1 IgG应答在血清阴性儿童中相关免疫学;免疫应答;免疫系统的组成部分;病毒学
SARS-CoV-2 infection in children typically results in asymptomatic or mild disease. There is a paucity of studies on SARS-CoV-2 antiviral immunity in African children. We investigated SARS-CoV-2-specific T cell responses in 71 unvaccinated asymptomatic South African children who were seropositive or seronegative for SARS-CoV-2. SARS-CoV-2-specific CD4+ T cell responses were detectable in 83% of seropositive and 60% of seronegative children. Although the magnitude of the CD4+ T cell response did not differ significantly between the two groups, their functional profiles were distinct, with SARS-CoV-2 seropositive children exhibiting a higher proportion of polyfunctional T cells compared to their seronegative counterparts. The frequency of SARS-CoV-2-specific CD4+ T cells in seronegative children was associated with the endemic human coronavirus (HCoV) HKU1 IgG response. Overall, the presence of SARS-CoV-2-responding T cells in seronegative children may result from cross-reactivity to endemic coronaviruses and could contribute to the relative protection from disease observed in SARS-CoV-2-infected children. SARS-CoV-2-specific T cell responses are detected in 60% of seronegative children Similar magnitude T cell response between seropositive and seronegative children Seronegative children exhibit a lower proportion of polyfunctional T cells CoV-2-specific T cell and endemic HKU1 IgG responses correlate in seronegative children Immunology; Immune response; Components of the immune system; Virology
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DOI：
10.1183/13993003.00285-2021
发表时间：
2022-01
期刊：
The European respiratory journal
影响因子：
--
作者：
Riou C;Schäfer G;du Bruyn E;Goliath RT;Stek C;Mou H;Hung D;Wilkinson KA;Wilkinson RJ
通讯作者：
Wilkinson RJ
影响因子：
30.3
作者：
Bogunovic D;Merad M
通讯作者：
Merad M
影响因子：
--
作者：
Mutavhatsindi, Hygon;Riou, Catherine
通讯作者：
Riou, Catherine
影响因子：
32.4
作者：
Jarjour NN;Masopust D;Jameson SC
通讯作者：
Jameson SC
影响因子：
8.8
作者：
Cotugno N;Ruggiero A;Bonfante F;Petrara MR;Zicari S;Pascucci GR;Zangari P;De Ioris MA;Santilli V;Manno EC;Amodio D;Bortolami A;Pagliari M;Concato C;Linardos G;Campana A;Donà D;Giaquinto C;CACTUS Study Team;Brodin P;Rossi P;De Rossi A;Palma P
通讯作者：
Palma P