Analysis of motion of the rectum during preoperative intensity modulated radiation therapy for rectal cancer using cone-beam computed tomography.
Analysis of motion of the rectum during preoperative intensity modulated radiation therapy for rectal cancer using cone-beam computed tomography.
复制标题
使用锥束计算机断层扫描术中直肠癌术中直肠运动的运动分析。
DOI：
10.1186/s13014-014-0311-6
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发表时间：
2015-01-08
期刊：
影响因子：
--
通讯作者：
Nakagawa K
中科院分区：
文献类型：
--
作者：
Yamashita H;Takenaka R;Sakumi A;Haga A;Otomo K;Nakagawa K
本研究的目的是在直肠癌放化疗（CRT）期间使用CBCT扫描量化直肠的分次间运动以及直肠和膀胱体积。此外，还评估了直肠癌同步积分增强调强放射治疗（SIB-IMRT）的更佳边界。本研究中有32例直肠癌患者接受术前CRT。在所有计划CT和CBCT（第1、7、13、19、25天）上勾画每个直肠和膀胱的轮廓。通过在计划CT上向直肠添加边缘（0、3、5、7、10和15 mm）来配置靶体积。计算每个边缘的直肠体积超过目标体积的相应百分比。分析膀胱体积超出计划CT膀胱体积的百分比和直肠重心的运动。本研究分析了32例患者的计划CT和每5例CBCT的系列。直肠体积有周复一周缩小的趋势。每例患者的32个系列中，CBCT上直肠超过目标体积的百分比的平均值（± SD）分别为20.7 ± 12.5%、7.2 ± 8.3%、3.9 ± 5.9%、2.1 ± 3.9%、0.7 ± 1.8%、和0.1 ± 0.3%。膀胱容积变化率与直肠重心运动无相关性。在这项研究中，我们估计直肠的运动使用计划CT和CBCT。在仰卧位直肠癌的SIB-IMRT期间，10至15 mm是直肠的足够边缘。
The purpose of the present study was to quantify the inter-fractional motion of the rectum and the rectal and bladder volumes using CBCT scans taken during chemoradiation therapy (CRT) for rectal cancer. Also, assessment was made for a better margin for simultaneous integrated boost - intensity modulated radiation therapy (SIB-IMRT) for rectal cancer. There were 32 patients in this study undergoing preoperative CRT for rectal cancer. Each rectum and bladder was contoured on all planning CTs and CBCTs (day 1, 7, 13, 19, 25). The target volume was configured by adding margins (0, 3, 5, 7, 10, and 15 mm) to the rectum on planning CT. The respective percentage of rectal volume that exceeds the target volume was calculated for each of these margins. The percentage of bladder volume that exceeds the bladder volume in the planning CT and motion of the center of gravity of rectum were also analyzed. Planning CTs and series of each 5 CBCTs for 32 patients were analyzed in this study. The rectal volume tended to shrink week after week. The mean values (± SD) in the 32 series per patient of the percentage of rectum on the CBCTs exceeding target volume in which the margins of 0, 3, 5, 7, 10, and 15 mm were added to the rectum on planning CT were 20.7 ± 12.5%, 7.2 ± 8.3%, 3.9 ± 5.9%, 2.1 ± 3.9%, 0.7 ± 1.8%, and 0.1 ± 0.3%, respectively. No association was seen between the percentage of changes of bladder volume and motion of rectal centroid. In this study, we estimated the motion of the rectum using planning CT and CBCT. Ten to fifteen mm is a sufficient margin for the rectum during SIB-IMRT for rectal cancer in the supine position.
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DOI：
10.1186/1748-717x-6-63
发表时间：
2011-06-08
期刊：
Radiation oncology (London, England)
影响因子：
--
作者：
Mok H;Crane CH;Palmer MB;Briere TM;Beddar S;Delclos ME;Krishnan S;Das P
通讯作者：
Das P
DOI：
10.1016/s0360-3016(02)02753-0
发表时间：
2002-06-01
影响因子：
7
作者：
Nuyttens, JJ;Robertson, JM;Martinez, A
通讯作者：
Martinez, A
DOI：
10.1016/j.ijrobp.2008.02.032
发表时间：
2008-07-01
影响因子：
7
作者：
Tournel, Koen;De Ridder, Mark;Storme, Guy
通讯作者：
Storme, Guy
影响因子：
158.5
作者：
Sauer, R;Becker, H;Raab, R
通讯作者：
Raab, R
影响因子：
5.7
作者：
Nijkamp, Jasper;de Jong, Rianne;Marijnen, Corrie
通讯作者：
Marijnen, Corrie