Serotonergic innervation of the human amygdala and evolutionary implications.
Serotonergic innervation of the human amygdala and evolutionary implications.
复制标题
DOI：
10.1002/ajpa.23896
复制
发表时间：
2019-11
影响因子：
2.8
通讯作者：
Semendeferi K
中科院分区：
文献类型：
--
作者：
Lew CH;Hanson KL;Groeniger KM;Greiner D;Cuevas D;Hrvoj-Mihic B;Schumann CM;Semendeferi K
多巴胺能系统参与社会情绪行为的调节，并严重支配杏仁核，杏仁核是社会脑回路的关键结构。我们量化了人类杏仁核四个主要核团的多巴胺能轴突密度，并根据先前发表的黑猩猩和倭黑猩猩的数据集检查了我们的结果。福尔马林固定的死后组织切片的杏仁核从六个人进行了染色的5-羟色胺转运蛋白（SERT）利用免疫组织化学。SERT免疫反应（IR）轴突纤维密度在杏仁核的外侧，基底，副基底和中央核采用无偏体视学进行定量。采用非参数统计分析来研究人类杏仁核之间SERT-IR轴突密度的差异，以及人类与先前发表的黑猩猩和倭黑猩猩数据之间的差异。人类表现出独特的杏仁核神经支配的模式，SERT-IR轴突密度显着更大的中央核相比，外侧核。SERT-IR轴突密度显着大于人类相比，黑猩猩在基底，副基底，中央核。SERT-IR轴突密度更大，在人类相比，倭黑猩猩在辅助基底和中央核。SERT-ir轴突在杏仁核中分布的人类模式补充了人类进化中杏仁核中神经元的重新分布。目前的研究结果表明，人类，倭黑猩猩和黑猩猩杏仁核中认知和自主神经通路的差异性多巴胺能调节可能有助于社会行为的物种水平差异。
The serotonergic system is involved in the regulation of socio-emotional behavior and heavily innervates the amygdala, a key structure of social brain circuitry. We quantified serotonergic axon density of the four major nuclei of the amygdala in humans, and examined our results in light of previously published data sets in chimpanzees and bonobos. Formalin-fixed postmortem tissue sections of the amygdala from six humans were stained for serotonin transporter (SERT) utilizing immunohistochemistry. SERT-immunoreactive (ir) axon fiber density in the lateral, basal, accessory basal, and central nuclei of the amygdala was quantified using unbiased stereology. Nonparametric statistical analyses were employed to examine differences in SERT-ir axon density between amygdaloid nuclei within humans, as well as differences between humans and previously published data in chimpanzees and bonobos. Humans displayed a unique pattern of serotonergic innervation of the amygdala, and SERT-ir axon density was significantly greater in the central nucleus compared to the lateral nucleus. SERT-ir axon density was significantly greater in humans compared to chimpanzees in the basal, accessory basal, and central nuclei. SERT-ir axon density was greater in humans compared to bonobos in the accessory basal and central nuclei. The human pattern of SERT-ir axon distribution in the amygdala complements the redistribution of neurons in the amygdala in human evolution. The present findings suggest that differential serotonergic modulation of cognitive and autonomic pathways in the amygdala in humans, bonobos, and chimpanzees may contribute to species-level differences in social behavior.
登录
查看更多内容
DOI：
10.1002/cne.23118
发表时间：
2012-09-01
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Barger N;Stefanacci L;Schumann CM;Sherwood CC;Annese J;Allman JM;Buckwalter JA;Hof PR;Semendeferi K
通讯作者：
Semendeferi K
影响因子：
1.7
作者：
KLING A;DUNNE K
通讯作者：
DUNNE K
影响因子：
4.7
作者：
Azmitia, Efrain C.;Singh, Jorawer S.;Whitaker-Azmitia, Patricia M.
通讯作者：
Whitaker-Azmitia, Patricia M.
影响因子：
10.6
作者：
Bertolino, A;Arciero, G;Scarabino, T
通讯作者：
Scarabino, T
影响因子：
56.9
作者：
Hariri, AR;Mattay, VS;Weinberger, DR
通讯作者：
Weinberger, DR