Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia.
Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia.
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DOI：
10.1038/s41467-021-22788-8
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发表时间：
2021-04-30
影响因子：
16.6
通讯作者：
Bechtold DA
中科院分区：
文献类型：
--
作者：
Hayter EA;Wehrens SMT;Van Dongen HPA;Stangherlin A;Gaddameedhi S;Crooks E;Barron NJ;Venetucci LA;O'Neill JS;Brown TM;Skene DJ;Trafford AW;Bechtold DA
心脏中的电活动表现出24小时节律性，并且可能致命的心律失常更可能在一天中的特定时间发生。在这里，我们证明了大脑和心脏内的昼夜节律钟在窦房（SA）和房室（AV）结活动中设定每日节律，并施加一天中的时间依赖性室性心律失常的易感性。重要的是，从自主神经系统和心肌细胞时钟到SA和AV结的昼夜节律输入的平衡不同，这使得心脏传导系统在行为常规和睡眠-觉醒定时的突然转变期间对解耦敏感。我们的研究结果揭示了心脏传导系统昼夜节律控制的功能分离和对心律失常的固有易感性。心脏功能在白天和晚上会有很大的波动，但这不仅仅是我们行为变化的结果。作者强调了人体生物钟在调节心脏电活动中的作用，包括对心律失常的时间依赖性易感性。
Electrical activity in the heart exhibits 24-hour rhythmicity, and potentially fatal arrhythmias are more likely to occur at specific times of day. Here, we demonstrate that circadian clocks within the brain and heart set daily rhythms in sinoatrial (SA) and atrioventricular (AV) node activity, and impose a time-of–day dependent susceptibility to ventricular arrhythmia. Critically, the balance of circadian inputs from the autonomic nervous system and cardiomyocyte clock to the SA and AV nodes differ, and this renders the cardiac conduction system sensitive to decoupling during abrupt shifts in behavioural routine and sleep-wake timing. Our findings reveal a functional segregation of circadian control across the heart’s conduction system and inherent susceptibility to arrhythmia. Cardiac function fluctuates greatly across the day and night, but this is not simply a consequence of our changing behaviour. The authors highlight the role of the body’s circadian clock in regulating the heart electrical activity, including a time-of-day dependent susceptibility to cardiac arrhythmias.
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影响因子：
5.5
作者：
D'Souza A;Wang Y;Anderson C;Bucchi A;Baruscotti M;Olieslagers S;Mesirca P;Johnsen AB;Mastitskaya S;Ni H;Zhang Y;Black N;Cox C;Wegner S;Bano-Otalora B;Petit C;Gill E;Logantha SJRJ;Dobrzynski H;Ashton N;Hart G;Zhang R;Zhang H;Cartwright EJ;Wisloff U;Mangoni ME;da Costa Martins PA;Piggins HD;DiFrancesco D;Boyett MR
通讯作者：
Boyett MR
影响因子：
20.1
作者：
Cerrone, M;Colombi, B;Priori, SG
通讯作者：
Priori, SG
DOI：
10.1016/0165-1838(95)00104-2
发表时间：
1996-02-05
期刊：
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
影响因子：
--
作者：
Gatti, PJ;Johnson, TA;Massari, VJ
通讯作者：
Massari, VJ
影响因子：
4.8
作者：
Guo, YF;Stein, PK
通讯作者：
Stein, PK
影响因子：
3.7
作者：
Clasen, Lukas;Eickholt, Christian;Makimoto, Hisaki
通讯作者：
Makimoto, Hisaki