A seroepidemiologic study of Reston ebolavirus in swine in the Philippines.
A seroepidemiologic study of Reston ebolavirus in swine in the Philippines.
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DOI：
10.1186/1746-6148-8-82
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发表时间：
2012-06-18
影响因子：
2.6
通讯作者：
Morikawa S
中科院分区：
文献类型：
--
作者：
Sayama Y;Demetria C;Saito M;Azul RR;Taniguchi S;Fukushi S;Yoshikawa T;Iizuka I;Mizutani T;Kurane I;Malbas FF Jr;Lupisan S;Catbagan DP;Animas SB;Morales RG;Lopez EL;Dazo KR;Cruz MS;Olveda R;Saijo M;Oshitani H;Morikawa S
埃博拉病毒在人类和非人类灵长类动物中引起病毒性出血热，在非洲流行。莱斯顿埃博拉病毒（REBOV）在食蟹猴（Macaca fascicularis）中引起了几次动物流行病，但与任何人类疾病无关。2008年底，菲律宾首次在猪中发现了REBOV感染。2008年在潘加西南和布拉坎的两个受REBOV影响的农场共采集了215份猪血清，使用多种血清诊断系统检测了REBOV特异性抗体的存在。还对在非流行病地区塔拉克收集的总共98份猪血清进行了检测，以阐明REBOV感染在菲律宾一般猪群中的患病率。在多重血清学诊断系统中，受影响农场约70%的猪血清对REBOV抗体呈阳性。另一方面，在塔拉克采集的猪血清在任何诊断系统中均未显示阳性反应。2008年受影响农场的猪中REBOV感染的高流行率表明猪对REBOV感染易感。研究中使用的多种血清学检测被认为对菲律宾猪REOBV感染的未来监测有用。
Ebola viruses cause viral hemorrhagic fever in humans and non-human primates and are endemic in Africa. Reston ebolavirus (REBOV) has caused several epizootics in cynomolgus monkeys (Macaca fascicularis) but is not associated with any human disease. In late 2008, REBOV infections were identified in swine for the first time in the Philippines. A total of 215 swine sera collected at two REBOV-affected farms in 2008, in Pangasinan and Bulacan, were tested for the presence of REBOV-specific antibodies using multiple serodiagnosis systems. A total of 98 swine sera collected in a non-epizootic region, Tarlac, were also tested to clarify the prevalence of REBOV infection in the general swine population in the Philippines. Some 70 % of swine sera at the affected farms were positive for REBOV antibodies in the multiple serodiagnosis systems. On the other hand, none of the swine sera collected in Tarlac showed positive reactions in any of the diagnosis systems. The high prevalence of REBOV infection in swine in the affected farms in 2008 suggests that swine is susceptible for REBOV infection. The multiple serological assays used in the study are thought to be useful for future surveillance of REOBV infection in swine in the Philippines.
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影响因子：
3.8
作者：
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通讯作者：
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