Comparing social attention in autism and amygdala lesions: effects of stimulus and task condition.
Comparing social attention in autism and amygdala lesions: effects of stimulus and task condition.
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DOI：
10.1080/17470919.2011.561547
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发表时间：
2011
影响因子：
2
通讯作者：
Adolphs R
中科院分区：
文献类型：
--
作者：
Birmingham E;Cerf M;Adolphs R
杏仁核在定向凝视和注意社会显著刺激方面起着关键作用。先前的研究表明，SM患者患有罕见的双侧杏仁核病变，无法注视和利用面部眼睛的信息。杏仁核功能障碍也被认为是自闭症谱系障碍（ASD）的一个促成因素，这与一些ASD患者眼睛注视减少的报道是一致的。然而，ASD和杏仁核病变患者之间的详细比较尚未进行。在这里，我们进行了这样的比较，使用眼动追踪到包含人脸的复杂社交场景。我们向参与者提供了三个任务条件。在中性任务中，参与者必须确定场景发生在什么样的房间里。在描述任务中，参与者描述场景。在社会注意力任务中，参与者推断场景中的人在引导他们的注意力。与对照组相比，SM组看眼睛的时间更少，而看嘴巴的时间更多，这与早期的研究结果一致。ASD组也有一种趋势，即花在眼睛上的时间更少，尽管这取决于特定的图像和任务。当任务需要社会关注时，对照组和SM会更多地看眼睛，而ASD组则不会。这种损伤模式表明，SM较少看眼睛是因为刺激驱动的对社会特征的注意力不足，而ASD患者较少看眼睛是因为他们通常对社会相关信息不敏感，并且不能将注意力作为任务要求的功能进行调节。我们的结论是，ASD的社会注意障碍的来源可能来自杏仁核的上游，而不是杏仁核本身。
The amygdala plays a critical role in orienting gaze and attention to socially salient stimuli. Previous work has demonstrated that SM a patient with rare bilateral amygdala lesions, fails to fixate and make use of information from the eyes in faces. Amygdala dysfunction has also been implicated as a contributing factor in autism spectrum disorders (ASD), consistent with some reports of reduced eye fixations in ASD. Yet, detailed comparisons between ASD and patients with amygdala lesions have not been undertaken. Here we carried out such a comparison, using eye tracking to complex social scenes that contained faces. We presented participants with three task conditions. In the Neutral task, participants had to determine what kind of room the scene took place in. In the Describe task, participants described the scene. In the Social Attention task, participants inferred where people in the scene were directing their attention. SM spent less time looking at the eyes and much more time looking at the mouths than control subjects, consistent with earlier findings. There was also a trend for the ASD group to spend less time on the eyes, although this depended on the particular image and task. Whereas controls and SM looked more at the eyes when the task required social attention, the ASD group did not. This pattern of impairments suggests that SM looks less at the eyes because of a failure in stimulus-driven attention to social features, whereas individuals with ASD look less at the eyes because they are generally insensitive to socially relevant information and fail to modulate attention as a function of task demands. We conclude that the source of the social attention impairment in ASD may arise upstream from the amygdala, rather than in the amygdala itself.
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影响因子：
2.6
作者：
Crawford, JR;Garthwaite, PH
通讯作者：
Garthwaite, PH
影响因子：
1.8
作者：
Birmingham, Elina;Bischof, Walter F.;Kingstone, Alan
通讯作者：
Kingstone, Alan
影响因子：
--
作者：
DAMASIO, AR;MAURER, RG
通讯作者：
MAURER, RG
DOI：
10.1111/j.1749-6632.2010.05445.x
发表时间：
2010-01-01
期刊：
YEAR IN COGNITIVE NEUROSCIENCE 2010
影响因子：
--
作者：
Adolphs, Ralph
通讯作者：
Adolphs, Ralph
影响因子：
9.2
作者：
Adolphs, Ralph;Spezio, Michael L.;Parlier, Morgan;Piven, Joseph
通讯作者：
Piven, Joseph