Increased cerebral cortex activation in stroke patients during electrical stimulation of cerebellar fastigial nucleus with functional near-infrared spectroscopy.
Increased cerebral cortex activation in stroke patients during electrical stimulation of cerebellar fastigial nucleus with functional near-infrared spectroscopy.
复制标题
用功能性近红外光谱电刺激小脑顶核可增加中风患者的大脑皮层激活
DOI：
10.3389/fnins.2022.895237
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发表时间：
2022
影响因子：
4.3
通讯作者：
Ma, Chao
中科院分区：
文献类型：
--
作者：
Ma, Haiyun;Zhai, Yujia;Xu, Zhen;Fan, Shengnuo;Wu, Xian;Xu, Jing;Wu, Shaoling;Ma, Chao
关键词：
小脑顶核（FNS）的电刺激已被证明可以保护动物免受脑缺血损伤。然而，皮质激活的变化作为对 FNS 的反应尚未在人类身上得到证实。本研究旨在检测中风患者大脑功能连接的变化，并通过测量中风患者和健康对照（HC）大脑皮层的氧合血红蛋白浓度（HBO）来研究FNS引起的皮层激活。这项研究招募了 20 名中风患者和 20 名 HC，所有以下因素均匹配：年龄、性别和 BMI。实验阶段由任务前基线、FNS 任务期和任务后基线组成。 FNS任务周期包含5个块，每个块包含静止状态（30秒）和FNS状态（30秒）。在整个实验过程中，通过功能性近红外光谱 (fNIRS) 从前额皮质 (PFC)、运动皮质 (MC) 和枕叶皮质 (OC) 获取 HBO 信号。使用皮尔逊相关系数计算两组之间的静息态功能连接强度，并使用一般线性模型（GLM）分别计算脑卒中患者和健康人在FNS期间39个fNIRS通道的激活。中风患者的耦合强度在以下区域显着降低：右侧 MC 和左侧 MC（t = 4.65，p = 0.0007）、右侧 MC 和左侧 OC（t = 2.93，p = 0.04）、左侧 MC 和左侧 OC（t = 2.81，p = 0.04）。在中风患者中，与静息状态相比，FNS 状态期间双侧 PFC 和双侧 MC 区域 12 个通道（CH）之间的脑氧合血红蛋白（ΔHBO）变化显着增加（FDR 校正 p < 0.05）。在 HC 中，FNS 期间左侧 PFC 中仅增加了 1 个通道（FDR 校正 p < 0.05）。通过使用 FNS 和 fNIRS 技术，发现中风患者的功能连接特征下降。还注意到 FNS 激活 PFC 和 MC 区域。这些发现可能有助于指导中风患者的功能康复。
Electrical stimulation of the cerebellar fastigial nucleus (FNS) has been shown to protect animals against cerebral ischemic injury. However, the changes in cortical activation as a response to FNS have not been illustrated in humans. This study aims to detect functional connectivity changes in the brain of stroke patients, and investigate the cortical activation caused by FNS through measuring the oxygenated hemoglobin concentration (HBO) in the cerebral cortex of stroke patients and healthy controls (HCs). This study recruited 20 patients with stroke and 20 HCs with all the following factors matched: age, gender and BMI. The experiment session was made up of the pre-task baseline, FNS task period, and post-task baseline. FNS task period contains 5 blocks, each block encompassing the resting state (30 s) and the FNS state (30 s). HBO signals were acquired by functional near-infrared spectroscopy (fNIRS) from the Prefrontal Cortex (PFC), the Motor Cortex (MC) and the Occipital Cortex (OC) throughout the experiment. The Pearson correlation coefficient was used to calculate the resting-state functional connectivity strength between the two groups, and the general linear model (GLM) was used to calculate the activation of 39 fNIRS channels during FNS in stroke patients and HCs, respectively. The coupling strength of stroke patients were significantly decreased in the following regions: right MC and left MC (t = 4.65, p = 0.0007), right MC and left OC (t = 2.93, p = 0.04), left MC and left OC (t = 2.81, p = 0.04). In stroke patients, the changes in cerebral oxygenated hemoglobin (ΔHBO) among 12 channels (CH) in the bilateral PFC and bilateral MC regions were significantly increased during the FNS state (FDR corrected p < 0.05) compared with the resting state. In HCs, only 1 channel was increased (FDR corrected p < 0.05) in the left PFC during FNS. By using the FNS and fNIRS techniques, the characteristics of functional connectivity were found to decrease in stroke patients. It was also noticed that FNS activates the PFC and MC regions. These findings may help to guide functional rehabilitation in stroke patients.
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影响因子：
3.3
作者：
Golanov EV;Regnier-Golanov AS;Britz GW
通讯作者：
Britz GW
影响因子：
5.7
作者：
Di Rosa, Elisa;Brigadoi, Sabrina;Vallesi, Antonino
通讯作者：
Vallesi, Antonino
影响因子：
8.3
作者：
Park CH;Chang WH;Ohn SH;Kim ST;Bang OY;Pascual-Leone A;Kim YH
通讯作者：
Kim YH
影响因子：
5.7
作者：
Svoboda, Karel;Lie, Nuo
通讯作者：
Lie, Nuo
DOI：
10.1523/jneurosci.3945-16.2017
发表时间：
2017-09-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Song C;Sandberg K;Andersen LM;Blicher JU;Rees G
通讯作者：
Rees G