Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients.
Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients.
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DOI：
10.1016/j.celrep.2021.108728
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发表时间：
2021-02-09
期刊：
影响因子：
8.8
通讯作者：
Bertoletti A
中科院分区：
文献类型：
--
作者：
Tan AT;Linster M;Tan CW;Le Bert N;Chia WN;Kunasegaran K;Zhuang Y;Tham CYL;Chia A;Smith GJD;Young B;Kalimuddin S;Low JGH;Lye D;Wang LF;Bertoletti A
病毒特异性体液免疫和细胞免疫协同作用，以保护宿主免受病毒感染。我们调查了12例有症状的急性SARS-CoV-2感染患者从发病到康复或死亡的病毒学和免疫学参数的动态变化。我们用抗体和循环T细胞对呼吸道中的SARS-CoV-2病毒RNA进行定量，这些抗体和循环T细胞对各种结构蛋白（核蛋白[NP]、膜蛋白[M]、ORF 3a和刺突蛋白）和非结构蛋白（ORF 7/8、NSP 7和NSP 13）具有特异性。尽管体液应答的快速诱导和数量与疾病严重程度的增加相关，但在轻度疾病和加速病毒清除的患者中存在分泌干扰素（IFN）-γ的SARS-CoV-2特异性T细胞的早期诱导。这些发现为早期功能性SARS-CoV-2特异性T细胞的预后价值提供了支持，这对疫苗设计和免疫监测具有重要意义。Tan等人纵向分析了COVID-19患者从疾病发作到消退或死亡的病毒学和免疫学参数。在轻度疾病和快速病毒清除的患者中观察到功能性SARS-CoV-2特异性T细胞的早期诱导。这支持了检测SARS-CoV-2特异性T细胞的预后价值。
Virus-specific humoral and cellular immunity act synergistically to protect the host from viral infection. We interrogate the dynamic changes of virological and immunological parameters in 12 patients with symptomatic acute SARS-CoV-2 infection from disease onset to convalescence or death. We quantify SARS-CoV-2 viral RNA in the respiratory tract in parallel with antibodies and circulating T cells specific for various structural (nucleoprotein [NP], membrane [M], ORF3a, and spike) and non-structural (ORF7/8, NSP7, and NSP13) proteins. Although rapid induction and quantity of humoral responses associate with an increase in disease severity, early induction of interferon (IFN)-γ-secreting SARS-CoV-2-specific T cells is present in patients with mild disease and accelerated viral clearance. These findings provide support for the prognostic value of early functional SARS-CoV-2-specific T cells with important implications in vaccine design and immune monitoring. Tan et al. longitudinally analyzed the virological and immunological parameters in COVID-19 patients from disease onset until resolution or death. Early induction of functional SARS-CoV-2-specific T cells was observed in patients with mild disease and rapid viral clearance. This supports the prognostic value of detecting SARS-CoV-2-specific T cells.
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