3D GRASE PROPELLER: improved image acquisition technique for arterial spin labeling perfusion imaging.
3D GRASE PROPELLER: improved image acquisition technique for arterial spin labeling perfusion imaging.
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DOI：
10.1002/mrm.22768
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发表时间：
2011-07
影响因子：
3.3
通讯作者：
Kraft, Robert A.
中科院分区：
文献类型：
--
作者：
Tan, Huan;Hoge, W. Scott;Hamilton, Craig A.;Guenther, Matthias;Kraft, Robert A.
动脉自旋标记（ASL）是一种可以定量测量脑血流量（CBF）的无创技术。传统的ASL采用2D EPI或螺旋采集轨迹，而单发3D GRASE由于其固有的信噪比优势和空间覆盖范围，在ASL中越来越受欢迎。然而，3D GRASE的一个主要限制是由T2衰减引起的平面模糊。提出了一种结合3D GRASE和PROPELLER轨迹（3DGP）的新技术，可以在不牺牲灌注灵敏度或增加总扫描时间的情况下最大限度地减少平面模糊。以3×3×5mm3名义体素大小获取全脑灌注图像，Q2TIPS-FAIR作为ASL准备序列。在不到4分钟的时间内，通过GE 1.5T扫描仪获得了5名健康受试者的数据。虽然与3D GRASE在CBF定量方面表现出良好的一致性，但3DGP显示出减少平面模糊，改善解剖细节，高重复性和抗运动的稳健性，使其适合常规临床使用。
Arterial spin labeling (ASL) is a non-invasive technique that can quantitatively measure cerebral blood flow (CBF). While traditionally ASL employs 2D EPI or spiral acquisition trajectories, single-shot 3D GRASE is gaining popularity in ASL due to inherent SNR advantage and spatial coverage. However, a major limitation of 3D GRASE is through-plane blurring caused by T2 decay. A novel technique combining 3D GRASE and a PROPELLER trajectory (3DGP) is presented to minimize through-plane blurring without sacrificing perfusion sensitivity or increasing total scan time. Full brain perfusion images were acquired at a 3×3×5mm3 nominal voxel size with Q2TIPS-FAIR as the ASL preparation sequence. Data from 5 healthy subjects was acquired on a GE 1.5T scanner in less than 4 minutes per subject. While showing good agreement in CBF quantification with 3D GRASE, 3DGP demonstrated reduced through-plane blurring, improved anatomical details, high repeatability and robustness against motion, making it suitable for routine clinical use.
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3.3
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