Association of Trypanosoma cruzi infection with risk factors and electrocardiographic abnormalities in northeast Mexico.
Association of Trypanosoma cruzi infection with risk factors and electrocardiographic abnormalities in northeast Mexico.
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DOI：
10.1186/1471-2334-14-117
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发表时间：
2014-03-01
影响因子：
3.7
通讯作者：
Galaviz-Silva L
中科院分区：
文献类型：
--
作者：
Molina-Garza ZJ;Rosales-Encina JL;Mercado-Hernández R;Molina-Garza DP;Gomez-Flores R;Galaviz-Silva L
美洲锥虫病是一种重大疾病和公共卫生问题，由原生动物寄生虫克氏锥虫引起。克氏锥虫的流行情况尚未得到完整记录，新莱昂州对此问题的报道也很少。本研究的目的是更新克氏锥虫感染的血清流行率，包括与这种感染相关的危险因素的流行病学分析以及对感染者的心电图（ECG）评估。使用酶联免疫吸附测定和间接血凝测定对来自墨西哥新莱昂州 10 个城市的 2,688 名个体的血清进行了评估。对克氏锥虫血清阳性受试者进行了心电图病例对照研究，结果按性别和年龄与同一地区血清阴性居民进行匹配。采用 χ2 和 Fisher 精确检验的单变量分析来确定血清阳性与年龄（岁）、性别和心电图变化之间的关联。然后进行多变量分析以计算克氏锥虫血清阳性与危险因素之间的奇数比。血清阳性率为1.93%（52/2,688）。在心电图研究中，22.85%（8/35）的感染者表现出心电图异常。格氏锥蝽是唯一报道的媒介。主要风险因素是天花板建筑材料（P ≤ 0.0024）、家畜（P ≤ 0.0001）和居住在农村城市（P ≤ 0.0025）。这些发现表明恰加斯病的患病率比之前报道的 (0.2%) 高 10 倍，这意味着墨西哥东北部存在严重的公共卫生威胁。本研究建立的流行病学概况与墨西哥其他地区的流行病学概况不同，墨西哥其他地区的人口居住在距锥蝽很近的地方。
American trypanosomiasis is a major disease and public health issue, caused by the protozoan parasite Trypanosoma cruzi. The prevalence of T. cruzi has not been fully documented, and there are few reports of this issue in Nuevo Leon. The aim of this study was to update the seroprevalence rate of T. cruzi infection, including an epidemiological analysis of the risk factors associated with this infection and an electrocardiographic (ECG) evaluation of those infected. Sera from 2,688 individuals from 10 municipalities in the state of Nuevo Leon, Mexico, were evaluated using an enzyme-linked immunosorbent assay and an indirect hemagglutination assay. An ECG case–control study was performed in subjects seropositive for T. cruzi and the results were matched by sex and age to seronegative residents of the same localities. A univariate analysis with χ2 and Fisher’s exact tests was used to determine the association between seropositivity and age (years), sex, and ECG changes. A multivariate analysis was then performed to calculate the odd ratios between T. cruzi seropositivity and the risk factors. The seropositive rate was 1.93% (52/2,688). In the ECG study, 22.85% (8/35) of the infected individuals exhibited ECG abnormalities. Triatoma gerstaeckeri was the only vector reported. The main risk factors were ceiling construction material (P ≤ 0.0024), domestic animals (P ≤ 0.0001), and living in rural municipalities (P ≤ 0.0025). These findings demonstrate a 10-fold higher prevalence of Chagas disease than previously reported (0.2%), which implies a serious public health threat in northeastern Mexico. The epidemiological profile established in this study differs from that found in the rest of Mexico, where human populations live in close proximity to domiciliary triatomines.
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影响因子：
2.7
作者：
Breniere, Simone Frederique;Bosseno, Marie-France;Lozano-Kasten, Felipe
通讯作者：
Lozano-Kasten, Felipe
DOI：
10.1590/s1020-49892004000500009
发表时间：
2004-05-01
期刊：
Revista Panamericana de Salud Pública
影响因子：
--
作者：
Capps, Linnea;Abad, Begoña
通讯作者：
Abad, Begoña
DOI：
10.1590/s0074-02762002000700004
发表时间：
2002-10-01
期刊：
Memórias do Instituto Oswaldo Cruz
影响因子：
--
作者：
Sánchez-Guillén, MC;Barnabé, C;Pérez-Fuentes, R
通讯作者：
Pérez-Fuentes, R
影响因子：
1.7
作者：
Lambert, Rebecca Click;Kolivras, Korine N.;Paulson, Sally L.
通讯作者：
Paulson, Sally L.
DOI：
10.1590/s0074-02762006000400001
发表时间：
2006-06-01
期刊：
Memórias do Instituto Oswaldo Cruz
影响因子：
--
作者：
Cruz-Reyes, Alejandro;Pickering-López, José Miguel
通讯作者：
Pickering-López, José Miguel