Influence of acute or chronic administration of ovarian hormones on the effects of desipramine in the forced swim test in female rats.
Influence of acute or chronic administration of ovarian hormones on the effects of desipramine in the forced swim test in female rats.
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DOI：
10.1007/s00213-014-3510-9
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发表时间：
2014-09
影响因子：
3.4
通讯作者：
Frazer, Alan
中科院分区：
文献类型：
--
作者：
Shah, Aparna;Frazer, Alan
性别可能会影响抗抑郁药(AD)的治疗结果。为了在临床前解决这一问题，我们研究了卵巢激素对去卵巢雌性大鼠AD治疗的潜在影响。在第一项研究中，在强迫游泳实验(FST)中，观察了雌激素和孕酮对选择性去甲肾上腺素再摄取抑制剂地昔帕明(DMI)抗抑郁药样作用的影响。在第二项研究中，研究了长期服用这些激素对长期服用DMI的效果的影响。在这项尖锐的研究中，激素阻断了DMI在FST中的作用，这一点从DMI与激素联合治疗的动物身上既没有减少不动也没有增加攀登行为来证明。海马突触体的浓度反应实验表明，激素处理的大鼠摄取~3H-NE的Km或Bmax没有变化。在慢性研究中，DMI在FST中的抗抑郁药样作用不能被长期给予激素阻断。有趣的是，激素影响了DMI的血清浓度。与服用安慰剂的大鼠相比，激素治疗的大鼠每天摄入10或15 mg/kg的动物体内的这些水平明显更高。急性给予激素可阻断DMI(在24小时内给药三次)对FST的影响。然而，长期服用这些激素并不能阻止长期服用DMI的效果(剂量可产生临床相关的血清浓度)。
Gender may influence antidepressant (AD) treatment outcome. In order to address this pre-clinically, the potential effects of ovarian hormones on AD treatment in ovariectomized female rats were investigated. In the first study, the effect of acute administration of estrogen and progesterone on the antidepressant-like effects of desipramine (DMI), a selective norepinephrine reuptake inhibitor (SNRI), was investigated in the forced swimming test (FST). In the second study, the effect of chronic administration of these hormones on the effects of chronically administered DMI was investigated. In the acute study, the hormones blocked the effects of DMI in the FST as demonstrated by the absence of either a reduction in immobility or an increase in climbing behavior in animals treated with DMI in combination with the hormones. Concentration-response experiments on hippocampal synaptosomes revealed no changes in the Km or Bmax for uptake of 3H-NE in hormone-treated rats. In the chronic study, the antidepressant-like effects of DMI in the FST were not blocked by chronic administration of hormones. Interestingly, the hormones affected the serum concentrations of DMI. These levels were significantly higher in animals receiving 10 or 15 mg/kg/day in hormone-treated rats as compared to those with placebo. Acute administration of hormones blocked the effects of DMI (given three times over 24 h) in the FST. However, chronic administration of these hormones failed to block the effects of chronically administered DMI (at a dose that produces clinically relevant serum concentrations).
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影响因子：
3.4
作者：
BIEGON, A;SAMUEL, D
通讯作者：
SAMUEL, D
影响因子：
10.6
作者：
Furmaga, Havan;Shah, Aparna;Frazer, Alan
通讯作者：
Frazer, Alan
影响因子：
3.7
作者：
Martínez-Mota, L;Estrada-Camarena, E;Fernández-Guasti, A
通讯作者：
Fernández-Guasti, A
DOI：
10.1080/10401230701653294
发表时间：
2007-10-01
期刊：
Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists
影响因子：
--
作者：
Grigoriadis, Sophie;Robinson, Gail Erlick
通讯作者：
Robinson, Gail Erlick
影响因子：
6.6
作者：
Marcus, SM;Young, EA;Rush, AJ
通讯作者：
Rush, AJ