Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering.
Extracellular Matrix-Based Biomaterials for Cardiovascular Tissue Engineering.
复制标题
DOI：
10.3390/jcdd8110137
复制
发表时间：
2021-10-22
影响因子：
2.4
通讯作者：
Huang NF
中科院分区：
文献类型：
--
作者：
Khanna A;Zamani M;Huang NF
再生医学和组织工程策略在重塑、替换和再生受损心血管组织方面取得了显著进展。设计具有适当生化和力学特性的三维支架是工程组织工程替代的关键。细胞外基质（ECM）是一种动态支架结构，具有组织特异性的生化、生物物理和机械特性，可调节细胞行为并激活高度调节的信号通路。随着技术的进步，基于生物材料的支架已经被开发出来，可以更好地模拟生理ECM特性，提供调节细胞行为的信号提示，并形成功能性组织和器官。在这篇综述中，我们总结了体外、临床前和临床研究模型，这些模型已经被用于心血管再生医学中基于ecm的生物材料的设计。我们重点介绍了将ECM成分纳入生物材料支架的研究进展，利用生物制造和空间模式技术设计日益复杂的结构，ECM对血管分化和功能的调节，以及基于ECM的支架在血管移植中的应用。最后，我们讨论了用于心血管组织工程和临床翻译的下一代基于ecm的生物材料设计的挑战、未来前景和方向。
Regenerative medicine and tissue engineering strategies have made remarkable progress in remodeling, replacing, and regenerating damaged cardiovascular tissues. The design of three-dimensional (3D) scaffolds with appropriate biochemical and mechanical characteristics is critical for engineering tissue-engineered replacements. The extracellular matrix (ECM) is a dynamic scaffolding structure characterized by tissue-specific biochemical, biophysical, and mechanical properties that modulates cellular behavior and activates highly regulated signaling pathways. In light of technological advancements, biomaterial-based scaffolds have been developed that better mimic physiological ECM properties, provide signaling cues that modulate cellular behavior, and form functional tissues and organs. In this review, we summarize the in vitro, pre-clinical, and clinical research models that have been employed in the design of ECM-based biomaterials for cardiovascular regenerative medicine. We highlight the research advancements in the incorporation of ECM components into biomaterial-based scaffolds, the engineering of increasingly complex structures using biofabrication and spatial patterning techniques, the regulation of ECMs on vascular differentiation and function, and the translation of ECM-based scaffolds for vascular graft applications. Finally, we discuss the challenges, future perspectives, and directions in the design of next-generation ECM-based biomaterials for cardiovascular tissue engineering and clinical translation.
登录
查看更多内容
干细胞行为的细胞外基质调节。
影响因子：
1.4
作者：
Ahmed M;Ffrench-Constant C
通讯作者：
Ffrench-Constant C
DOI：
10.1073/pnas.93.8.3509
发表时间：
1996-04-16
影响因子：
11.1
作者：
Boudreau, N;Werb, Z;Bissell, MJ
通讯作者：
Bissell, MJ
影响因子：
4.9
作者：
Akbay, Esin;Onur, Mehmet Ali
通讯作者：
Onur, Mehmet Ali
影响因子：
5.6
作者：
Carvalho, Marta S.;Silva, Joao C.;Vashishth, Deepak
通讯作者：
Vashishth, Deepak
影响因子：
64.8
作者：
Bassat E;Mutlak YE;Genzelinakh A;Shadrin IY;Baruch Umansky K;Yifa O;Kain D;Rajchman D;Leach J;Riabov Bassat D;Udi Y;Sarig R;Sagi I;Martin JF;Bursac N;Cohen S;Tzahor E
通讯作者：
Tzahor E