Insect antimicrobial peptides and their applications.
Insect antimicrobial peptides and their applications.
复制标题
DOI：
10.1007/s00253-014-5792-6
复制
发表时间：
2014-07
影响因子：
5
通讯作者：
Yu, Xiao-Qiang
中科院分区：
文献类型：
--
作者：
Yi, Hui-Yu;Chowdhury, Munmun;Huang, Ya-Dong;Yu, Xiao-Qiang
关键词：
昆虫是抗菌肽/蛋白的主要来源之一。自1974年在家蚕蛹血淋巴中观察到抗菌活性及首次从家蚕蛹中分离纯化出抗菌肽以来，家蚕蛹的抗菌活性一直是人们关注的热点。自1980年从cecropia pupae开始，已纯化或鉴定出150多种昆虫抗菌肽。大多数昆虫AMP是小的和阳离子的，并且它们显示出对细菌和/或真菌以及一些寄生虫和病毒的活性。昆虫抗菌肽根据其结构或序列可分为4个家族：α-螺旋肽（天蚕素和moricin）、富含半胱氨酸的肽（昆虫防御素和drosomycin）、富含脯氨酸的肽（apidaecin、drosocin和lebocin）和富含甘氨酸的肽/蛋白（attacin和gloverin）。在昆虫AMP中，防御素、天蚕素、富含脯氨酸的肽和附着素是常见的，而gloverins和moricins仅在鳞翅目中被鉴定。大多数活性AMP是20-50个残基的小肽，其由较大的无活性前体蛋白或前蛋白产生，但gloverins（~14 kDa）和attacins（~20 kDa）是大的抗微生物蛋白。在这篇简短的综述中，我们将讨论几类昆虫抗菌肽的现有知识和最新进展，包括昆虫防御素，天蚕抗菌肽，attacins，lebocins和其他富含脯氨酸的肽，gloverins和moricins，重点是结构-功能关系及其潜在的应用。
Insects are one of the major sources of antimicrobial peptides/proteins (AMPs). Since observation of antimicrobial activity in the hemolymph of pupae from the giant silk moths Samia Cynthia and Hyalophora cecropia in 1974 and purification of first insect AMP (cecropin) from H. cecropia pupae in 1980, over 150 insect AMPs have been purified or identified. Most insect AMPs are small and cationic, and they show activities against bacteria and/or fungi, as well as some parasites and viruses. Insect AMPs can be classified into four families based on their structures or unique sequences: the α-helical peptides (cecropin and moricin), cysteine-rich peptides (insect defensin and drosomycin), proline-rich peptides (apidaecin, drosocin and lebocin), and glycine-rich peptides/proteins (attacin and gloverin). Among insect AMPs, defensins, cecropins, proline-rich peptides and attacins are common, while gloverins and moricins have been identified only in Lepidoptera. Most active AMPs are small peptides of 20–50 residues, which are generated from larger inactive precursor proteins or pro-proteins, but gloverins (~14 kDa) and attacins (~20 kDa) are large antimicrobial proteins. In this mini-review, we will discuss current knowledge and recent progress in several classes of insect AMPs, including insect defensins, cecropins, attacins, lebocins and other proline-rich peptides, gloverins, and moricins, with a focus on structural-functional relationships and their potential applications.
登录
查看更多内容
影响因子：
1.3
作者：
Barr, SC;Rose, D;Jaynes, JM
通讯作者：
Jaynes, JM
影响因子：
2.7
作者：
BONMATIN, JM;BONNAT, JL;ACHSTETTER, T
通讯作者：
ACHSTETTER, T
影响因子：
3.8
作者：
Boulanger, N;Brun, R;Bulet, P
通讯作者：
Bulet, P
DOI：
10.1111/j.1432-1033.1997.00614.x
发表时间：
1997-07-15
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Axen, A;Carlsson, A;Bennich, H
通讯作者：
Bennich, H
影响因子：
3.8
作者：
Abdel-latief, M.;Hilker, M.
通讯作者：
Hilker, M.