Thrombospondin-2 and SPARC/osteonectin are critical regulators of bone remodeling.
Thrombospondin-2 and SPARC/osteonectin are critical regulators of bone remodeling.
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DOI：
10.1007/s12079-009-0076-0
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发表时间：
2009-12
影响因子：
4.1
通讯作者：
Hankenson KD
中科院分区：
文献类型：
--
作者：
Delany AM;Hankenson KD
血小板反应蛋白-2（TSP 2）和骨粘连蛋白/BM-40/BMP是由骨细胞高度表达的基质细胞蛋白。缺乏这些蛋白质的小鼠在骨骼中表现出表型改变，并且这些表型在骨重建改变的条件下最明显。例如，TSP 2缺失小鼠具有更高的皮质骨体积，并且对与卵巢切除术相关的骨丢失具有抗性，而SPARC缺失小鼠具有减少的小梁骨体积，并且未能证明响应于骨合成代谢甲状旁腺激素治疗方案的骨矿物质密度增加。在体外，骨髓基质细胞（MSC）的骨祖细胞从TSP 2基因敲除小鼠的增殖增加，但延迟形成矿化基质。类似地，在SPARC缺失的MSC的培养物中，成骨细胞分化和矿化基质形成减少。总的来说，TSP 2和TGF β 1都积极影响成骨细胞分化。有趣的是，这两种基质细胞蛋白似乎通过可能涉及Notch信号系统的机制影响MSC的命运。本文综述了TSP 2和TSP 3在调节骨结构、功能和重塑中的作用，并通过体外和体内研究进行了确定。
Thrombospondin-2 (TSP2) and osteonectin/BM-40/SPARC are matricellular proteins that are highly expressed by bone cells. Mice deficient in either of these proteins show phenotypic alterations in the skeleton, and these phenotypes are most pronounced under conditions of altered bone remodeling. For example, TSP2-null mice have higher cortical bone volume and are resistant to bone loss associated with ovariectomy, whereas SPARC-null mice have decreased trabecular bone volume and fail to demonstrate an increase in bone mineral density in response to a bone-anabolic parathyroid hormone treatment regimen. In vitro, marrow stromal cell (MSC) osteoprogenitors from TSP2-null mice have increased proliferation but delayed formation of mineralized matrix. Similarly, in cultures of SPARC-null MSCs, osteoblastic differentiation and mineralized matrix formation are decreased. Overall, both TSP2 and SPARC positively influence osteoblastic differentiation. Intriguingly, both of these matricellular proteins appear to impact MSC fate through mechanisms that could involve the Notch signaling system. This review provides an overview of the role of TSP2 and SPARC in regulating bone structure, function, and remodeling, as determined by both in vitro and in vivo studies.
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影响因子：
4.8
作者：
Barker, TH;Baneyx, G;Sage, EH
通讯作者：
Sage, EH
DOI：
10.1006/bbrc.1999.1380
发表时间：
1999-09-24
影响因子：
3.1
作者：
Carron, JA;Bowler, WB;Gallagher, JA
通讯作者：
Gallagher, JA
影响因子：
15.9
作者：
Delany, AM;Amling, M;Canalis, E
通讯作者：
Canalis, E
DOI：
10.1073/pnas.88.19.8636
发表时间：
1991-10-01
影响因子：
11.1
作者：
BORNSTEIN, P;DEVARAYALU, S;FRAMSON, P
通讯作者：
FRAMSON, P
影响因子：
8
作者：
Chamboredon, S;Briggs, J;Castellazzi, M
通讯作者：
Castellazzi, M