Is the intergenerational transmission of smoking from mother to child mediated by children's behavior problems?
Is the intergenerational transmission of smoking from mother to child mediated by children's behavior problems?
复制标题
吸烟从母亲传给孩子的代际传播是否是由儿童行为问题介导的？
DOI：
10.1093/ntr/ntr328
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Weden,MargaretM
中科院分区：
文献类型：
--
作者：
Miles,JeremyNV;Weden,MargaretM
IntroductionA先前的论文使用潜在类别分析将个体分配到4个青少年/年轻成人吸烟轨迹类别中的1个，然后建立了母亲在怀孕前、怀孕期间和怀孕后吸烟与这些类别之间的关联。在本文中，我们研究了一种可能的途径，这种关系：母亲在怀孕期间吸烟可能会引发的行为轨迹，增加了问题行为的可能性一般，其中吸烟是一个manifest.MethodsWe使用的行为问题指数测量从8岁到12岁作为一个潜在的调解人。我们在多项逻辑回归中使用了路径分析建模方法（使用Mplus）估计直接和间接影响（通过行为问题）之间的母亲吸烟模式和儿童轨迹class.ResultsWe发现小，但统计学显着的间接影响，通过行为问题，从母亲吸烟到儿童吸烟轨迹的成员在所有3个吸烟类，相对于非吸烟轨迹，表明部分调解。中介效应与母亲怀孕后吸烟，没有统计学意义的中介效应被发现吸烟前或在pregnancy.ConclusionsThe结果提供了没有证据表明，母亲在怀孕期间吸烟对儿童吸烟轨迹的影响是由问题行为介导的。出生后吸烟对儿童吸烟轨迹的影响似乎部分由问题行为介导，支持怀孕期间吸烟的行为而不是生理影响，但不排除更复杂的生理途径。
IntroductionA previous paper used latent class analysis to assign individuals to 1 of 4 adolescent/young adult smoking trajectory classes and then established an association between maternal smoking before, during, and after pregnancy and these classes. In this paper, we examine one possible pathway for this relationship: that maternal smoking during pregnancy may set off a behavioral trajectory which increases the likelihood of problem behaviors generally, of which smoking is one manifestation.MethodsWe used the Behavior Problems Index measure from age 8 through age 12 as a potential mediator. We used a path analysis modeling approach within a multinomial logistic regression (using Mplus) to estimate direct and indirect effects (via behavioral problems) between maternal smoking pattern and child trajectory class.ResultsWe found small but statistically significant indirect effects via behavioral problems from maternal smoking to child smoking trajectory for membership in all 3 smoking classes, relative to the nonsmoking trajectory, indicating partial mediation. Mediated effects were associated with maternal smoking after pregnancy, no statistically significant mediated effects were found for smoking before or during pregnancy.ConclusionsThe results provided no evidence that the effects of maternal smoking during pregnancy on child smoking trajectory are mediated by problem behavior. Effects from smoking after birth to child smoking trajectory appear to be partially mediated by problem behavior, supporting a behavioral rather than physiological effect of smoking during pregnancy but not ruling out more complex physiological pathways.
登录
查看更多内容
ε-氨基己酸对纤溶酶原和纤溶酶总体构象的影响
DOI：
--
发表时间：
1975
期刊：
影响因子：
--
作者：
B. Violand;J. Sodetz;F. Castellino
通讯作者：
F. Castellino
人肺肿瘤和正常肺组织中纤溶酶原激活剂的含量和特征。
影响因子：
11.2
作者：
G. Markus;H. Takita;S. Camiolo;J. Corasanti;J. Evers;G. Hobika
通讯作者：
G. Hobika
影响因子：
64.8
作者：
ASTEDT, B;HOLMBERG, L
通讯作者：
HOLMBERG, L
影响因子：
6.5
作者：
G. Wijngaards;C. Kluft;E. Groeneveld
通讯作者：
E. Groeneveld
DOI：
10.1016/s0021-9258(19)81106-7
发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
T. Wun;W. Schleuning;E. Reich
通讯作者：
E. Reich