c-Myb oncoprotein is an essential target of the dleu2 tumor suppressor microRNA cluster.
c-Myb oncoprotein is an essential target of the dleu2 tumor suppressor microRNA cluster.
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DOI：
10.4161/cbt.7.11.6722
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发表时间：
2008-11
影响因子：
3.6
通讯作者：
Thomas-Tikhonenko A
中科院分区：
文献类型：
--
作者：
Chung EY;Dews M;Cozma D;Yu D;Wentzel EA;Chang TC;Schelter JM;Cleary MA;Mendell JT;Thomas-Tikhonenko A
The dleu2 tumor suppressor locus encodes two microRNAs, miR-15a and miR-16, which are thought to play an important role in B-cell neoplasms. However, relatively little is known about proteins that regulate or are regulated by this microRNA cluster. Here we demonstrate that the Pax5 oncoprotein downregulates the dleu2 gene and at the same time boosts expression of its own heterodimeric partner c-Myb. Interestingly, c-Myb upregulation occurs primarily at a post-transcriptional level, suggesting that it might be a target for microRNAs such as miR-15a/16. Indeed, miR-15a/16 have predicted binding sites in the c-Myb 3′-UTR and through them diminish protein output in luciferase sensor assays. Moreover, forced overexpression of miR-15a/16 reduces endogenous c-Myb levels and compromises Pax5 function. Conversely, restoration of c-Myb levels partly alleviates tumors suppressive effects of miR-15a/16, suggesting that c-Myb is a key downstream target of this microRNA cluster.
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影响因子：
56.9
作者：
Thai, To-Ha;Calado, Dinis Pedro;Rajewsky, Klaus
通讯作者：
Rajewsky, Klaus
影响因子：
20.3
作者：
Gururajan, M;Chui, R;Bondada, S
通讯作者：
Bondada, S
影响因子：
46.9
作者：
Jackson, AL;Bartz, SR;Linsley, PS
通讯作者：
Linsley, PS
DOI：
10.1073/pnas.89.4.1291
发表时间：
1992-02-15
影响因子：
11.1
作者：
DUDEK, H;TANTRAVAHI, RV;REDDY, EP
通讯作者：
REDDY, EP
影响因子：
64.8
作者：
Johnnidis, Jonathan B.;Harris, Marian H.;Camargo, Fernando D.
通讯作者：
Camargo, Fernando D.