Volatile anesthetics maintain tidal volume and minute ventilation to a greater degree than propofol under spontaneous respiration.
Volatile anesthetics maintain tidal volume and minute ventilation to a greater degree than propofol under spontaneous respiration.
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在自主呼吸情况下，挥发性麻醉剂对潮气量和分钟通气量的维持程度比丙泊酚更大。
DOI：
10.1186/s12871-021-01438-y
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发表时间：
2021-10-06
影响因子：
2.2
通讯作者：
Zhou C
中科院分区：
文献类型：
--
作者：
Hao X;Ou M;Li Y;Zhou C
尽管全麻药抑制自主呼吸，但全麻药对呼吸功能的综合影响尚不清楚。目的：观察不同种类和剂量的全身麻醉药对非插管小鼠自主呼吸的影响。以最低肺泡浓度(MAC)/半数有效剂量(ED50)的0.5、1.0和2.0倍的剂量在体内分别给予异丙酚和依托咪酯等静脉麻醉药和七氟醚和异氟醚等吸入麻醉药，以诱导翻正反射(LOR)的丧失。采用全身体积描记(WBP)技术，在无气管插管的非限制性条件下测量呼吸参数。同时测定全麻下呼吸对二氧化碳(CO2)敏感性的变化。在麻醉或CO2暴露期间连续记录呼吸频率(FR)、潮气量(TV)、分钟通气量(MV)、呼气时间(TE)、吸气时间(TI)、吸气/呼气时间比(I/E)和最大吸气流速。七氟醚或异氟醚的亚麻醉浓度(0.5MAC)增加了FR、TV和MV。吸入异氟醚和七氟醚后，CO2引起的FR、TV和MV的增加均减少。与吸入麻醉药相比，异丙酚和依托咪酯引起呼吸抑制，影响FR、TV和MV。在100%氧气中，异丙酚1.0倍ED50组的呼吸频率为69.63 ± 33.44次/分钟，依托咪酯组为155.68 ± 64.42次/分钟。在同一组中，呼吸频率在3%二氧化碳中分别为88.72 ± 34.51次/分钟和225.10 ± 59.82次/分钟，在5%二氧化碳中分别为144.17 ± 63.25次/分钟和197.70 ± 41.93次/分钟。与异丙酚治疗的小鼠相比，依托咪酯治疗的小鼠对二氧化碳的敏感性更高。此外，与同等剂量的依托咪酯、七氟醚和异氟醚相比，异丙酚引起的FR、MV和I/E比值的下降幅度更大(均P <； 0.05)。全身麻醉药对体内的自发呼吸有不同的调节作用。挥发性麻醉药在亚麻醉浓度时增加FR、TV和MV，而在较高浓度时降低FR。异丙酚持续抑制呼吸参数的程度大于依托咪酯。
Although general anesthetics depress spontaneous respiration, the comprehensive effect of general anesthetics on respiratory function remains unclear. We aimed to investigate the effects of general anesthetics on spontaneous respiration in non-intubated mice with different types and doses of general anesthetic. Adult C57BL/6 J mice were administered intravenous anesthetics, including propofol and etomidate, and inhalational anesthetics, including sevoflurane and isoflurane in vivo at doses of 0.5-, 1.0-, and 2.0-times the minimum alveolar concentration (MAC)/median effective dose (ED50) to induce loss of the righting reflex (LORR). Whole-body plethysmography (WBP) was applied to measure parameters of respiration under unrestricted conditions without endotracheal intubation. The alteration in respiratory sensitivity to carbon dioxide (CO2) under general anesthesia was also determined. The following respiratory parameters were continuously recorded during anesthesia or CO2 exposure: respiratory frequency (FR), tidal volume (TV), minute ventilation (MV), expiratory time (TE), inspiratory time (TI), and inspiratory–expiratory time ratio (I/E), and peak inspiratory flow. Sub-anesthetic concentrations (0.5 MAC) of sevoflurane or isoflurane increased FR, TV, and MV. With isoflurane and sevoflurane exposure, the CO2-evoked increases in FR, TV, and MV were decreased. Compared with inhalational anesthetics, propofol and etomidate induced respiratory suppression, affecting FR, TV, and MV. In 100% oxygen (O2), FR in the group that received propofol 1.0-times the ED50 was 69.63 ± 33.44 breaths/min compared with 155.68 ± 64.42 breaths/min in the etomidate-treated group. In the same groups, FR was 88.72 ± 34.51 breaths/min and 225.10 ± 59.82 breaths/min, respectively, in 3% CO2 and 144.17 ± 63.25 breaths/min and 197.70 ± 41.93 breaths/min, respectively, in 5% CO2. A higher CO2 sensitivity was found in etomidate-treated mice compared with propofol-treated mice. In addition, propofol induced a greater decrease in FR, MV, and I/E ratio compared with etomidate, sevoflurane, and isoflurane at equivalent doses (all P < 0.05). General anesthetics differentially modulate spontaneous breathing in vivo. Volatile anesthetics increase FR, TV, and MV at sub-anesthetic concentrations, while they decrease FR at higher concentrations. Propofol consistently depressed respiratory parameters to a greater degree than etomidate.
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DOI：
10.1523/jneurosci.1956-10.2010
发表时间：
2010-07-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Lazarenko RM;Fortuna MG;Shi Y;Mulkey DK;Takakura AC;Moreira TS;Guyenet PG;Bayliss DA
通讯作者：
Bayliss DA
影响因子：
5.5
作者：
Levitt, Erica S.;Abdala, Ana P.;Williams, John T.
通讯作者：
Williams, John T.
影响因子：
25
作者：
Mulkey, DK;Stornetta, RL;Guyenet, PG
通讯作者：
Guyenet, PG
影响因子：
4.6
作者：
Bastianini, Stefano;Alvente, Sara;Cohen, Gary
通讯作者：
Cohen, Gary
影响因子：
5.8
作者：
Stuth, Eckehard A. E.;Stucke, Astrid G.;Zuperku, Edward J.
通讯作者：
Zuperku, Edward J.