Costunolide alleviates hyperglycaemia-induced diabetic cardiomyopathy via inhibiting inflammatory responses and oxidative stress.
Costunolide alleviates hyperglycaemia-induced diabetic cardiomyopathy via inhibiting inflammatory responses and oxidative stress.
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DOI：
10.1111/jcmm.17686
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发表时间：
2023-03
影响因子：
5.3
通讯作者：
中科院分区：
文献类型：
--
作者：
高血糖诱导的心肌损伤促进糖尿病患者心力衰竭的诱导。抗氧化能力受损和持续的慢性炎症在糖尿病心肌病（DCM）的进展中起着至关重要的作用。Costuntantine（Cos）是一种具有抗炎和抗氧化特性的天然化合物，在各种炎症性疾病中表现出治疗效果。然而，Cos在糖尿病诱导的心肌损伤中的作用仍然知之甚少。在这项研究中，我们研究了Cos对DCM的影响，并探讨了可能的机制。向C57 BL/6小鼠腹膜内施用链脲佐菌素用于DCM诱导。在糖尿病小鼠的心脏组织和高葡萄糖（HG）刺激的心肌细胞中检测Cos介导的抗炎和抗氧化活性。Cos分别在糖尿病小鼠和H9 c2细胞中显著抑制HG诱导的纤维化反应。Cos的心脏保护作用可能与减少炎症细胞因子的表达和降低氧化应激有关。进一步的研究表明，Cos逆转糖尿病诱导的核因子-κB（NF-κB）激活，并减轻受损的抗氧化防御系统，主要是通过激活核因子-红细胞2 p45相关因子-2（Nrf-2）。Cos通过抑制NF-κB介导的炎症反应和激活Nrf-2介导的抗氧化作用减轻糖尿病小鼠的心脏损伤并改善心脏功能。因此，Cos可能是治疗DCM的潜在候选药物。
Hyperglycaemia‐induced myocardial injury promotes the induction of heart failure in diabetic patients. Impaired antioxidant capability and sustained chronic inflammation play a vital role in the progression of diabetic cardiomyopathy (DCM). Costunolide (Cos), a natural compound with anti‐inflammatory and antioxidant properties, has exhibited therapeutic effects in various inflammatory diseases. However, the role of Cos in diabetes‐induced myocardial injury remains poorly understood. In this study, we investigated the effect of Cos on DCM and explored the potential mechanisms. C57BL/6 mice were administered intraperitoneal streptozotocin for DCM induction. Cos‐mediated anti‐inflammatory and antioxidation activities were examined in heart tissues of diabetic mice and high glucose (HG)‐stimulated cardiomyocytes. Cos markedly inhibited HG‐induced fibrotic responses in diabetic mice and H9c2 cells, respectively. The cardioprotective effects of Cos could be correlated to the reduced expression of inflammatory cytokines and decreased oxidative stress. Further investigations demonstrated Cos reversed diabetes‐induced nuclear factor‐κB (NF‐κB) activation and alleviated impaired antioxidant defence system, principally via activation of nuclear factor‐erythroid 2 p45‐related factor‐2 (Nrf‐2). Cos alleviated cardiac damage and improved cardiac function in diabetic mice by inhibiting NF‐κB‐mediated inflammatory responses and activating the Nrf‐2‐mediated antioxidant effects. Therefore, Cos could be a potential candidate for the treatment of DCM.
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DOI：
10.2147/dmso.s30968
发表时间：
2013
期刊：
Diabetes, metabolic syndrome and obesity : targets and therapy
影响因子：
--
作者：
Chavali V;Tyagi SC;Mishra PK
通讯作者：
Mishra PK
影响因子：
8.2
作者：
Bugger, Heiko;Abel, E. Dale
通讯作者：
Abel, E. Dale
影响因子：
2.1
作者：
Hou, Jun;Zheng, Dezhi;Hu, Yonghe
通讯作者：
Hu, Yonghe
影响因子：
9
作者：
Christidi E;Brunham LR
通讯作者：
Brunham LR
影响因子：
6
作者：
Cheleschi, Sara;Tenti, Sara;Fioravanti, Antonella
通讯作者：
Fioravanti, Antonella