Uncovering the global host cell requirements for influenza virus replication via RNAi screening.

Uncovering the global host cell requirements for influenza virus replication via RNAi screening.
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DOI:
10.1016/j.micinf.2011.01.012
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发表时间:
2011-05
影响因子:
5.8
通讯作者:
Shaw ML
Shaw ML
中科院分区:
医学3区
文献类型:
--
作者:
Stertz S;Shaw ML

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流感病毒在其复制周期中依赖于许多宿主细胞功能。RNA干扰技术在全基因组水平上的应用,已经确定了病毒有效复制所必需的人类宿主因子,并为流感病毒如何在分子水平上与其宿主相互作用提供了新的见解。
Influenza virus is reliant on numerous host cell functions during its replication cycle. RNA interference technology, applied on a genome-wide level, has identified human host factors that are necessary for efficient virus replication and provides new insight into how influenza virus interacts with its host at the molecular level.
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